Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

Martins, Sandra; Amorim, Ricardo; Mota, Sílvia Coelho; Costa, Luís; Pardal, Fernando; Rodrigues, Mesquita; Longatto‐Filho, Adhemar

doi:10.1155/2015/131685

Cited by 9 publications

(7 citation statements)

References 45 publications

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“…Can Ki-67 level predict the tumor's capacity to metastasize to the lymph node? Martins et al could not nd a relationship between the Ki-67 index of metastatic lymph nodes and surveillance in colorectal cancers, but they stated that there was a positive relationship between the Ki-67 index of the primary tumor and the presence of lymph node metastasis [31]. In our study, we could not nd a signi cant relationship between the Ki-67 index of the primary tumor and other histopathological parameters or perfusion and metabolism parameters.…”

Section: Discussioncontrasting

confidence: 89%

Evaluation of blood supply and metabolism in tumor, axillary lymph node and normal breast tissue with F-18 FDG PET/CT in breast cancer: Comparison with pathological prognostic factors

Abdülrezzak

Akgün

Tutuş

et al. 2023

Preprint

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Background and purpose Perfusion parameters to be obtained in F-18 FDG PET/CT performed for staging in breast cancers may have prognostic predictions as well as glucose metabolism. The aim of this study was to evaluate the relationship between blood flow and glucose metabolism and histological parameters of primary tumor, normal mammary gland and axillary lymph nodes in breast cancer patients who underwent F-18 FDG PET/CT.Materials and methods Sixty six female patients (mean age 51 y ± 12,81) were prospectively included to this study. We performed dynamic blood flow (f) study that started with 296–444 MBq (8–12 mCi) F-18 FDG injection and lasted for 10 minutes, and glucose metabolism (m) imaging one hour later. On each frame, mean activity concentration (AC) values (Bq/mL) were recorded on a spherical volume of interest (VOI) having a volume of ~ 1 cm3 on the hottest voxel of primary tumor (T), across normal breast gland (NG) and ipsilaterally axillary lymph nodes (iLN). Correlations among PET parameters and estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (c-erbB2) and Ki67 index were analyzed.Results T volume (TV) ranged from 1.1 to 85.28 cm3 [median (IR): 6.44 (11.78)]. There were positive correlations between c-erbB2 and TACf and between c-erbB2 and iLNACf (p = 0.045, r = + 0.248; p = 0.050, r = + 0.242). In the ER positive (ERP) patients, TV and TACm were significantly lower than those of ER negative (ERN) (respectively p = 0.044 and p = 0.041). In patients with two positive Ki-67 indices, iLN-SUVmax was significantly higher than one-positive patients (p = 0.020). There was a negative correlation between NGACm and histological grade of tumor (p = 0.005, r=-0.365).Conclusions Being able to examine tumor tissue characteristics such as blood flow and glucose metabolism with a single diagnostic technique and to reveal its relationship with histological parameters can provide a reliable pretherapeutic evaluation in breast cancers.

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Section: Discussioncontrasting

confidence: 89%

Evaluation of blood supply and metabolism in tumor, axillary lymph node and normal breast tissue with F-18 FDG PET/CT in breast cancer: Comparison with pathological prognostic factors

Abdülrezzak

Akgün

Tutuş

et al. 2023

Preprint

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“…S ome st ud ies h ave re cog n i zed t h at t he proliferation-associated antigen Ki-67 is one of the best known predictors of survival in patients with several malignant diseases, such as lung cancer, breast cancer and prostate cancer 22,23,24 . In contrast, it has been reported that Ki-67 might not be the most suitable proliferation marker for use in colorectal cancer and cervical intraepithelial neoplasia 25,26 .…”

Section: Discussionmentioning

confidence: 92%

Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study

et al. 2017

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Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study Abstract: The aim of this study was to identify the expression of Ki-67 and MCM3 in oral squamous cell carcinoma (OSCC) as well as to address the correlation with patient survival and clinical features. Samples were collected from 51 patients with OSCC who presented for follow-up. Immunohistochemical expression of Ki-67 and MCM3 in all groups was performed. The scoring system was previous published by Tsurutani in 2005. We used Kappa index to evaluate observers agreement degree. The associations between protein expression and clinical variables were examined for statistical significance using the chi-squared test. The overall survival rates were estimated by the Kaplan-Meier method and the relationship between protein expression and survival was compared using the log-rank test (p < 0.05). The overall survival time for a patient with positive immunostaining for Ki-67 is shorter than for a patient with negative immunostaining, (log-rank test, p = 0.00882). Patients with tumor size T3 and T4 showed a statistically significant relationship with Ki-67 immunoexpression (log-rank test, p = 0.0174). The relationship between Ki-67 expression and the relation between age, gender, smoking, tumor site, lymph node metastasis and disease stage was not significant. The examiners agreement degree by Kappa presented p value < 0.05. There was not a significant correlation when we evaluated MCM3 expression regarding clinical characteristics and survival rate. From these results, the present study suggests that positive Ki-67 expression found in OSCC patients may contribute to predict the survival in OSCC samples, as well as the relation between the protein and the tumor size.

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“…Although the present study did not examine the Ki-67 labeling index, which has been widely used as a proliferation marker, several reports (8,(10)(11)(12)19) have suggested that LAT1 expression is significantly associated with the Ki-67 labeling index in various cancers. Conflicting results (21)(22)(23) have been reported regarding the associations between the Ki-67 labeling index and clinical outcomes in CRC patients. Allegra et al (22), in a study of CRC patients who underwent curative resection between November 1977 and December 1990, reported that patients with high Ki-67 expression had significantly improved disease-free survival and OS rates than those with low levels of Ki-67.…”

Section: Discussionmentioning

confidence: 99%

L‑type amino acid transporter 1 expression is upregulated and associated with cellular proliferation in colorectal cancer

et al. 2017

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Abstract.Previous studies have shown that the L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancer. Upregulated LAT1 expression is considered to be associated with cancer cell proliferation. In the present study, we investigated LAT1 expression in 210 patients with colorectal cancer (CRC) and 40 patients with colonic adenoma using an immunohistochemical method, and analyzed the associations between LAT1 expression and clinicopathological factors and prognosis. The biological significance of LAT1 was also examined under conditions with sub-normal amounts of essential amino acids using colon cancer cell lines. High expression of LAT1 was observed in 152 of 210 CRC patients (72.4%) and 12 of 40 patients with colonic adenoma (30%), and this difference in the frequency of LAT1 expression between CRC and adenoma was significant (P<0.001). High expression of LAT1 was associated with venous invasion (P=0.027). The restriction of amino acids suppressed cell proliferation in CRC cells with higher LAT1 expression, while cellular proliferation was not suppressed in the cells expressing lower levels of LAT1. Mammalian target of rapamycin (mTOR) expression was also downregulated under restricted availability of amino acids, suggesting that the restriction of amino acids induced an antitumor effect through inhibition of the LAT1/mTOR pathway. In summary, the present study demonstrated that LAT1 expression is frequently upregulated in CRC and is associated with cancer cell proliferation via the mTOR pathway.

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Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

Cited by 9 publications

References 45 publications

Evaluation of blood supply and metabolism in tumor, axillary lymph node and normal breast tissue with F-18 FDG PET/CT in breast cancer: Comparison with pathological prognostic factors

Evaluation of blood supply and metabolism in tumor, axillary lymph node and normal breast tissue with F-18 FDG PET/CT in breast cancer: Comparison with pathological prognostic factors

Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study

L‑type amino acid transporter 1 expression is upregulated and associated with cellular proliferation in colorectal cancer

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