Ki-67 cell proliferation in familial and in esporadic unilateral retinoblastoma: case report

Bonanomi, Maria Teresa Brizzi Chizzotti; Cresta, Fernando Betty; Tokunaga, Clayton César; Santo, Ruth Miyuki; Maia, Otacílio de Oliveira; Takahashi, Walter Yukihiko

doi:10.1590/s0004-27492007000200029

Cited by 2 publications

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References 10 publications

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“…Complementing with biomarkers has shown to be of benefit in the determination of prognosis of the paediatric patients with RbT. Studies have shown that increased expression of cell proliferation biomarkers such as Ki67 is associated with advanced tumour stage and poor clinical outcomes 13–15. Other tumour markers such as p53 have been found to correlate significantly with the HHRFs including massive choroidal invasion and positive surgical margin of the optic nerve 16…”

Section: Introductionmentioning

confidence: 99%

Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study

2022

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ObjectivesThis study aims to investigate the expression of Ki67 in formalin-fixed paraffin-embedded tissue blocks from patients with a diagnosis of retinoblastoma tumour (RbT) as well as determining its association with histopathological high-risk factors (HHRFs).Methods and analysisRetrospectively, a total of 194 eyeball specimens from 163 children with RbT were reviewed at Muhimbili National Hospital between 2009 and 2013. Immunohistochemical expression of Ki67 using MIB-1 antibody (Abcam, batch ab93680, Cambridge, UK) was determined and correlated with the conventional HHRFs. The predictors of Ki67 expression were determined using binary logistic regression model in multivariate analysis. A two-tailed p<0.05 was considered statistically significant.ResultsMajority (67.5%) of the patients had leukocoria and extraocular disease was found in 20.9% of all the patients. High expression of Ki67 was present in 63.8% of the 80 eyeballs that were tested. Massive choroidal invasion (adjusted OR (AOR)=9.32, 95% CI=2.82 to 10.89), positive retrolaminar optic nerve invasion (AOR=3.01, 95% CI=4.43 to 9.11), positive surgical margin (AOR=7.10, 95% CI=1.63 to 11.40) and pT4 (AOR=7.49, 95% CI=0.12 to 0.89) were the potential HHRFs that were associated with Ki67 overexpression.ConclusionOverexpression of Ki67 may be of prognostic value for patients with RbT as it has been shown in the present study that high expression was common in tumours with massive choroidal invasion, positive retrolaminar optic nerve invasion, positive surgical margin and advanced tumour stage, which are the conventional HHRFs associated with prognosis of RbT.

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Section: Introductionmentioning

confidence: 99%

Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study

2022

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Ki-67 – new faces of an old player

et al. 2009

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The Ki-67 protein was isolated twenty-five years ago and has become the first histological marker of proliferating cells until now. This molecule with a unique structure possesses such fundamental biological functions that are essential for normal cell proliferation. Since the Ki-67 protein is present in every dividing cell (G1, S, G2/M phase) but is absent from the resting cells (G0 phase) it is very much suitable for identifying the proliferating fraction of cells. Thus, it provides essential information concerning the malignancy of a tumor and about the prediction of response to a certain therapy. Based on its important role in cell proliferation, the Ki-67 protein might also play a role in tumor genesis. In their present work the authors discuss the history and the properties of Ki-67, its role in cell cycle regulation and its prognostic importance in different malignant disorders.

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Ki-67 cell proliferation in familial and in esporadic unilateral retinoblastoma: case report

Abstract: The familial retinoblastoma, besides the earlier age presentation, showed 45.8% more Ki-67 positive cells than the same stage sporadic one. This proliferation rate may explain the earlier presentation age of the tumor in the inherited disease.

Cited by 2 publications

References 10 publications

Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study

Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study

Ki-67 – new faces of an old player

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