Key roles of nitric oxide and cyclic GMP in nonadrenergic and noncholinergic inhibition in rat ileum

Kanada, Atsunori; Hata, Fumiaki; Suthamnatpong, Naowarat; Maehara, Tomofumi; Ishii, Toshiaki; Takeuchi, Tadayoshi; Yagasaki, Osamu

doi:10.1016/0014-2999(92)90372-b

Cited by 73 publications

(42 citation statements)

References 20 publications

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“…In the present study, complete relaxation of rat iliac arteries by acetylcholine was obtained with a 14-fold increase in cGMP values. In other visceral smooth muscles, in which NO-mediated relaxation occurs, increases in CGMP following EFS, similar to that (Grous, Ormsbee & Barnette, 1990;Kanada et al 1992).…”

Section: Discussionsupporting

confidence: 81%

Relaxation mechanisms induced by stimulation of nerves and by nitric oxide in sheep urethral muscle.

Garcia-Pascual

Triguero

1994

The Journal of Physiology

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1. Isolated transverse and longitudinally oriented preparations of sheep urethra precontracted with noradrenaline responded to electrical field stimulation (EFS) with stimulus-dependent non-adrenergic, non-cholinergic (NANC) relaxations. 2. Exogenous nitric oxide (NO) (acidified NaNO2), S-nitroso-L-cysteine (NC), sodium nitroprusside (SNP), 8-Br-cGMP, dibutyryl-cAMP, forskolin and isoprenaline each relaxed precontracted transverse urethral preparations in a concentration-dependent manner in order of potency: NC > forskolin > isoprenaline = SNP > NO > 8-Br-cGMP = dibutyryl-cAMP. Longitudinally oriented preparations responded to NO and NC with concentration-dependent relaxation, no different from that observed in transverse strips. 3. Methylene blue (MB) and oxyhaemoglobin (HbO2) mechanism independent of NO generation. 9. A dense network of NADPH diaphorase-positive fibres associated with both the circular and longitudinal smooth muscle layers of sheep urethra was found. 10. The possibility that a nitrosyl compound which releases NO in the target tissue is the NANC transmitter in sheep urethra is discussed. The data also suggest a role for increased cGMP levels in the relaxation mechanisms, whereas changes in cAMP levels, phosphoinositide hydrolysis or K+ channel activation do not seem to be involved.

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Section: Discussionsupporting

confidence: 81%

Relaxation mechanisms induced by stimulation of nerves and by nitric oxide in sheep urethral muscle.

Garcia-Pascual

Triguero

1994

The Journal of Physiology

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“…However, increased evidence suggests that NO is a central and peripheral neuronal messenger or a new kind of neurotransmitter (Snyder & Bredt, 1991). It has been reported that NO and cGMP are involved in non-adrenergic, noncholinergic relaxation (Kanada et al 1992;Liu, Crawley, Rohde, Evans & Barnes, 1992 (Yamamoto et al 1993) and in intact rabbits (Halbrugge et al 1991). Addition of L-arginine, a precursor of NO (Palmer et al 1987;Palmer, Rees, Ashton & Moncada, 1988), attenuates the inhibition of NA overflow by NO synthesis inhibitors (Yamamoto et at.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide donors enhanced Ca2+ currents and blocked noradrenaline‐induced Ca2+ current inhibition in rat sympathetic neurons.

Chen

Schofield

1995

The Journal of Physiology

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“…In contrast, inhibitory motor neurons of descending relaxation are variable from region to region of the intestinal tract. The role of nitric oxide in the descending relaxation was shown in the rat ileum (Kanada et al, 1992;Kanada et al, 1993), proximal colon (Hata et al, 1990a) and distal colon (Grider, 1993;Okishio et al, 2000a). Some studies also reported a role of vasoactive intestinal peptide (VIP) in the descending relaxation in the middle of distal colon (Grider and Makhlouf, 1986;Grider and Rivier, 1990;Grider, 1993) and the distal colon (Okishio et al, 2000a) of the rat.…”

Section: Introductionmentioning

confidence: 97%

Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal

Okishio

Takeuchi

Fujita

et al. 2005

J. Smooth Muscle Res.

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Recently an essential role of interstitial cells of Cajal (ICC) within myenteric plexus (ICC-MY) was suggested in ascending contraction and descending relaxation in the mouse ileum. The role of ICC in these neural reflexes was examined in the distal colonic segments prepared from the wild type and c-kit mutant, W/W V mice, in the present study. Localized distension of the segments from the wild type mice by using a small balloon resulted in ascending contraction and descending relaxation. In the segments from the mutant mice, localized distension also induced these neural reflexes similar to those observed in the wild type mice. Immunohistochemical examination demonstrated that ICC-MY and ICC present in muscle layers (ICC-IM) were severely disrupted in the mutant mouse, but only ICC, present within submucosal plexus (ICC-SMP), remained unchanged. In the small strips with ICC-SMP absent prepared from the mutant mouse, electrical field stimulation induced contraction or relaxation in the absence or presence of atropine, respectively. It was suggested that ICC have no important role in the ascending and descending neural reflexes in the mouse distal colon, this is in direct contrast to the role of ICC-MY in the ileum.

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Key roles of nitric oxide and cyclic GMP in nonadrenergic and noncholinergic inhibition in rat ileum

Cited by 73 publications

References 20 publications

Relaxation mechanisms induced by stimulation of nerves and by nitric oxide in sheep urethral muscle.

Relaxation mechanisms induced by stimulation of nerves and by nitric oxide in sheep urethral muscle.

Nitric oxide donors enhanced Ca2+ currents and blocked noradrenaline‐induced Ca2+ current inhibition in rat sympathetic neurons.

Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal

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