Key role of oxidative stress in animal models of aminoglycoside nephrotoxicity revealed by a systematic analysis of the antioxidant-to-nephroprotective correlation

Casanova, Alfredo G.; Vicente-Vicente, Laura; Hernández-Sánchez, María Teresa; Pescador, Moisés; Prieto, Marta; Martı́nez-Salgado, Carlos; Morales, Ana Isabel; López‐Hernández, Francisco J.

doi:10.1016/j.tox.2017.04.015

Cited by 27 publications

(29 citation statements)

References 53 publications

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“…Various studies have indicated that gentamicin is able to disturb the redox balance via reducing the antioxidant activity of the body, such as SOD, GPx and CAT. Moreover, it results in high levels of free radicals and eventually multiple complications such as lipid peroxidation and MDA production (15,(17)(18)(19). We also achieved a similar result by measuring the serum levels of these enzymes as well as the MDA level, and showed that following the injection of gentamicin during a specific period, the level of antioxidant activity was reduced and, as a result, increased MDA levels.…”

Section: Discussionmentioning

confidence: 61%

“…We also achieved a similar result by measuring the serum levels of these enzymes as well as the MDA level, and showed that following the injection of gentamicin during a specific period, the level of antioxidant activity was reduced and, as a result, increased MDA levels. Several studies demonstrated incremental changes in serum or urine levels of various compounds such as urea and creatinine, albumin / creatinine ratio (16)(17)(18)(19)(20), due to decreased glomerular filtration rate, as well as NGAL (as a sensitive and specific marker for early detection of renal injury) (21-23) in renal injury. This finding has also been proved in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects

Hasanvand¹,

Kharazmkia²,

Mir³

et al. 2018

J Renal Inj Prev

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The most common symptoms of nephrotoxicity include decreased glomerular filtration, increased creatinine, blood urea nitrogen, uric acid, alkaline phosphatase, and electrolyte changes. Ferulic acid is a natural compound with a phenolic group which is found mainly in citrus, rice and coffee. In numerous studies, many roles have been identified for this substance, including anticancer, nephroprotective, hepatoprotective and anti-inflammatory activities.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects

Hasanvand¹,

Kharazmkia²,

Mir³

et al. 2018

J Renal Inj Prev

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“…Oxidative stress is thought to play a key role in the pathogenesis of nephrotoxicity both in vivo and in vitro (Casanova et al, ; Sinha et al, ). When there is an imbalance between ROS production and antioxidant defense system, oxidative stress occurs, and the antioxidant capacity of the cells is overwhelmed.…”

Section: Discussionmentioning

confidence: 99%

Rutin attenuates vancomycin‐induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress

Dai

Guo

et al. 2019

Phytotherapy Research

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Vancomycin is a glycopeptide antibiotic widely used to treat infections caused by methicillin-resistant Staphylococcus aureus. However, nephrotoxicity is a major adverse side effect, and the development of effective nephroprotective agents remains a priority in antimicrobial chemotherapy. In this study, we investigated the cell protective effects of the flavonol glycoside rutin against vancomycin-induced toxicity. Vancomycin added to porcine renal tubular LLC-PK1 cells caused an increase of production of intracellular reactive oxygen species and subsequent apoptotic cell death. Pretreatment of LLC-PK1 cells with rutin at 5, 10, and 20 μM for 2 hr prior to 2-mM vancomycin exposure for 24 hr significantly decreased intracellular reactive oxygen species and increased superoxide dismutase and catalase activities. Rutin pretreatment also protected cells from vancomycin-induced caspase activation, mitochondrial membrane depolarization, and subsequent apoptosis. This study demonstrates a protective effect of rutin and suggests that rutin coadministration is an alternative therapy for treatment of vancomycin-induced nephrotoxicity.

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“…Нефротоксичність реалізується за рахунок акумуляції в клітинах проксимальних канальців, зв'язування з фосфоліпідами мембран нефроцитів та пригнічення активності фосфоліпази, що призводить до лізосомального фосфоліпідозу. Крім того, пошкодження мітохондрій призводить до порушення мітоходріального дихання, зменшення активності Na + /K + -АТФази з розвитком оксидативного стресу, прогресування ниркової дисфункції, що супроводжується некрозом та апоптозом нефроцитів [7,8]. Оскільки патогенез ниркової патології характеризується прооксидантноантиоксидантним дисбалансом для дослідження було обраний похідне сірковмісних амінокислот -адеметіонін, дія якого спрямована на посилення антиоксидантного захисту, індукцію мембранопротекторних та цитопротекторних властивостей в поєднанні з виразною детоксикуючою активністю [9 -11].…”

Section: виконане експериментальне дослідження є фрагментом міжкафедрunclassified

“…Не менш інформативним показником при оцінці ступеня прооксидантно-антиоксидантного дисбалансу при ГН виступає ОМБ, оскільки окиснення білкових молекул під дією активних форм кисню призводить до незворотного ушкодження мембранних структур, порушення білками їх біологічної активності, обмінних та репаративних процесів, та, як наслідок, загибелі клітини [17]. Так, у тварин групи модельної патології застосування гентаміцину призвело до достовірного збільшення вмісту ОМБ у плазмі крові (на 54,7%), у тканині нирок -на 22,2%, порівняно з групою інтактного контролю.…”

Section: результати дослідження та їх обговоренняunclassified

Antioxidant Potential of Ademetionine in Gentamicine Nephropathy Progression

Драчук

Zamorskiy

Horoshko

2020

Act. Probl. of the Modern Med.

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ВІСНИК Українська медична стоматологічна академія 8 and progression of cardiovascular pathology, and a series of reports are devoted to the study and comparison of the distinctive features of free radical lipid oxidation and proteins in patients with endothelial dysfunction and various functional classes of angina. Despite the considerable period that has elapsed since the Chernobyl disaster, the medical and biological problems of long-term effects of ionizing radiation are remaining relevant. However, it should be noted that according to some authors, the ideas of lipid peroxidation, mainly based on in vitro studies, do not meet the requirements for recognizing the existence of a metabolic process or metabolic pathway. In recent years, the Department of Internal Medicine # 3 with Phthisiology has conducted the number of multidirectional studies focused on various aspects of free radical pathology in experimental and clinical medicine on cardiology, nephrology, immunology, haematology, pulmonology, and gastroenterology. According to the results of the literature review and comprehensive analysis of the conducted research, we can point out that the study of the role of free radical processes in experimental and clinical medicine is still remaining quite relevant. The scientific search and practical value of these studies can lead to new insight in the context of an overall deterioration of the environment and exposure to negative environmental factors.

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Key role of oxidative stress in animal models of aminoglycoside nephrotoxicity revealed by a systematic analysis of the antioxidant-to-nephroprotective correlation

Cited by 27 publications

References 53 publications

Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects

Ameliorative effect of ferulic acid on gentamicininduced nephrotoxicity in a rat model; role of antioxidant effects

Rutin attenuates vancomycin‐induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress

Antioxidant Potential of Ademetionine in Gentamicine Nephropathy Progression

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