Key mechanisms of the relationship between vitamin D and cardiovascular disease

Sytaya, Yu. S.

doi:10.15829/1560-4071-2022-4602

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…Уровень 25(ОН)Д или витамина Д, обладающего противовоспалительным, противодиабетическим, ангио-и кардиопротективными свой ствами, в группе молодых мужчин с НАЖБП находился в зоне дефицита, как мы показали сейчас и ранее [37], что также расценивается в настоящее время одним из предикторов развития СД2 и ССЗ [38][39][40][41][42]. Сам витамин Д играет важную роль в развитии инсулинорезистентности, так, например, у пациентов с ожирением и НАЖБП, уровень 25(ОН)Д положительно коррелирует с чувствительностью периферических тканей к инсулину [18,19].…”

Section: результаты и их обсуждениеunclassified

“…Сам витамин Д играет важную роль в развитии инсулинорезистентности, так, например, у пациентов с ожирением и НАЖБП, уровень 25(ОН)Д положительно коррелирует с чувствительностью периферических тканей к инсулину [18,19]. В настоящем исследовании мы показали также сочетанное снижение протективных факторов -витамина Д и ХС ЛПВП, в комплексе с гипертриглицеридемией и инсулинорезистентностью у молодых мужчин с НАЖБП, что, по нашему мнению, как и мнению ряда других авторов играет роль в увеличении сердечно-сосудистого риска и ухудшении прогноза жизни таких пациентов [1,[38][39][40][41][42].…”

Section: результаты и их обсуждениеunclassified

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Relationship between cardiometabolic risk factors and 25(OH)D levels in young men with non-alcoholic fatty liver disease

Yakovleva

Pirogova²

2023

jour

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Purpose of the study. Search for the relationship between cardiometabolic risk factors and 25(OH)D levels in young men with NAFLD. Materials and methods. A one-time study was carried out. The study included 102 men aged 18 to 44 years with no complaints and a verified diagnosis of NAFLD. NAFLD was confirmed in 70 people. All patients were divided into two groups: group I - persons with NAFLD (n=70); group II - persons without NAFLD (n=32); age differences are not statistically significant. All patients included in the study underwent laboratory and instrumental examination. Results. In 68.6% of men aged 18 to 44 years who had no previous complaints and a verified diagnosis of NAFLD, this diagnosis was made, of which steatosis of the liver was diagnosed in 100% of cases, NASH was diagnosed in 60.0%, in 34, 3% liver fibrosis on the background of steatosis and NASH, pathological changes in the liver in most cases were of a combined nature and increased with the progression of steatosis. Cardiometabolic risk factors such as abdominal obesity, NASH, and arterial hypertension predominate in patients with NAFLD. Patients with NAFLD showed a significant increase in laboratory markers of cardiometabolic risk against the background of insufficient supply of 25(OH)D; these disorders worsen as steatosis progresses. The identified relationships indicate a high cardiovascular risk and a worse prognosis for the life of young men with NAFLD. In patients with NAFLD, the number of laboratory markers of cardiometabolic risk is 4 or more in one patient, while their peers without NAFLD have no more than 2 components. Conclusion. Expanding our understanding of the role of vitamin D in pathological mechanisms in young people with NAFLD will make it possible to control the progression of insulin resistance through timely screening and vitamin D supplementation.

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Section: результаты и их обсуждениеunclassified

Relationship between cardiometabolic risk factors and 25(OH)D levels in young men with non-alcoholic fatty liver disease

Yakovleva

Pirogova²

2023

jour

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“…Генотип аа и аллель а гена VDR (ApaI-полиморфизм (rs7975232)) чаще встречались у больных ИБС, чем в группе сравнения (p=0,0001 и p=0,0001 соответственно, табл. 2), при этом наличие генотипа аа и аллеля а гена VDR ассоциируется с увеличением риска ИБС в 1,77 раза (OR=1,77 ( Распределение генотипов гена VDR (BsmI, ApaI-вариант) у больных ишемической болезнью сердца с однососудистым и многососудистым поражением коронарных артерий: р -доверительный уровень вероятности точного критерия Фишера при проверке однородности распределения генотипов и встречаемости аллелей при сравнении группы больных ИБС с однососудистым и многососудистым поражением коронарных артерий Distribution of genotypes of the VDR gene (BsmI, ApaI-variant) in coronary heart disease patients with single-vessel and multi-vessel coronary artery defeat: p -confidence level of probability of the Fisher's exact test when checking the uniformity of genotype distribution and alleles occurrence at comparing a group of coronary heart disease patients with single-vessel and multi-vessel coronary artery defeat В последние годы накоплено достаточно большое количество данных, свидетельствующих о том, что дефицит витамина D может быть связан с повышенным риском сердечно-сосудистых заболеваний (ССЗ) [23,24].…”

Section: в данной работе было проанализировано распределение генотипо...unclassified

“…Доказано, что дефицит витамина D связан с факторами риска ИБС, такими как артериальная гипертензия, дислипидемия и сахарный диабет [21,23].…”

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The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency

Belyaeva¹,

Du²,

Ionova³

et al. 2022

The Scientific Notes of the Pavlov university

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Introduction. Vitamin D deficiency may be an independent predictor of coronary heart disease (CHD) and the severity of coronary atherosclerosis. The results of studies of the association of various polymorphisms of the vitamin D receptor (VDR) gene with the risk and severity of CHD are contradictory, which necessitates the study of genetic variants of the VDR gene and the characteristics of the clinical course of CHD in the Russian population.The objective was to determine the distribution of genotypes of TaqI, BsmI and ApaI of polymorphic variants of the VDR gene and the level of vitamin D sufficiency in CHD patients with varying severity of CHD, residents of St. Petersburg.Methods and materials. The study included 407 CHD patients and 318 patients without clinical signs of CHD of comparable age (p>0.05). All CHD patients underwent coronary angiography. Typing of the VDR gene variants was performed by polymerase chain reaction and subsequent restriction analysis. Determination of the level of 25(OH)D blood serum was carried out by enzyme immunoassay.Results. Vitamin D deficiency was detected in 82 % of CHD patients, the content of 25(OH)D in blood serum was lower in CHD patients who had 2 or more myocardial infarctions (MI) than in those who had one MI (p=0.03). Vitamin D deficiency is associated with a 3.6-fold increased risk of multivessel disease (p=0.01). The presence of the aa genotype and the a allele (ApaI), the bb genotype and the b allele of the VDR gene (BsmI) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries.Conclusion. Vitamin D deficiency is typical for CHD patients and is associated with the severity of coronary atherosclerosis. The presence of aa genotype and a allele (ApaI polymorphism), bb genotype and b allele of the VDR gene (BsmI polymorphism) is associated with an increased risk of CHD and the severity of atherosclerotic lesions of the coronary arteries. TaqI polymorphism of the VDR gene is not associated with the risk of CHD.

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Vitamin D levels and TaqI, BsmI and ApaI variants of the vitamin D receptor gene in coronary heart disease patients with disease debut at different ages

Беркович¹,

Ionova²,

Du³

et al. 2023

The Scientific Notes of the Pavlov university

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Introduction. Vitamin D deficiency may be a natural predictor of the onset of coronary heart disease (CHD) and myocardial infarction (MI) at a young age. The results of studies of the various variants association of the vitamin D receptor (VDR) gene with the risk of CHD are contradictory, which leads to the study of genetic variants of the VDR gene as predictors of the onset of the disease at the age of 45 years and younger in the Russian population. The objective was to determine the distribution of TaqI, BsmI and ApaI genotypes of the VDR gene variants and the level of vitamin D sufficiency in CHD patients with different age of onset of the disease and myocardial infarction, among residents of St. Petersburg. Methods and materials. The study included 410 CHD patients and 320 examined patients without CHD clinical signs of comparable age (p>0.05). All patients with CHD underwent coronary angiography. Typing of VDR gene variants was carried out by polymerase chain reaction and subsequent restriction analysis. Determination of the level of 25(OH)D blood serum was carried out by enzyme immunoassay. Results. The level of 25(OH)D in the blood serum of CHD patients was lower than in the control group (15.61±0.52 ng/ml and 20.82±0.69 ng/ml respectively; p=0.001). Severe 25(OH)D deficiency was detected more often in CHD patients and was associated with an increased risk of CHD (23 % and 8 % respectively; p=0.001, OR=3.54 (1.88÷6.67)). The normal level of 25(OH)D sufficiency was more often detected in patients from the comparison group than in CHD patients, and was associated with a decrease of CHD risk (16 % and 4 % respectively; p=0.0002, OR=OR=0,21 (0,09÷0,48)). The presence of the aa genotype and the a allele (ApaI), the bb genotype and the b allele of the VDR gene (BsmI) is associated with an increased risk of CHD and the onset of the disease and MI at the age of 45 years and younger. Conclusions. Severe 25(OH)D deficiency is typical for CHD patients and was associated with an increased risk of CHD. The presence of the aa genotype and the a allele (ApaI), the bb genotype and the b allele of the VDR gene (BsmI) is associated with an increased risk of CHD and with the onset of the diseases and myocardial infarction at a young age. The TaqI variant of the VDR gene is not associated with the risk of CHD.

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Key mechanisms of the relationship between vitamin D and cardiovascular disease

Cited by 3 publications

References 41 publications

Relationship between cardiometabolic risk factors and 25(OH)D levels in young men with non-alcoholic fatty liver disease

Relationship between cardiometabolic risk factors and 25(OH)D levels in young men with non-alcoholic fatty liver disease

The severity of coronary artery defeat in coronary heart disease patients with different variants of the vitamin D receptor gene and the level of vitamin D sufficiency

Vitamin D levels and <i>TaqI</i>, <i>BsmI</i> and <i>ApaI</i> variants of the vitamin D receptor gene in coronary heart disease patients with disease debut at different ages

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