Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups

Matthews, Sara; Mai, Lei; Jeong, Chang‐Bum; Lee, Jae‐Seong; Zeng, Eddy Y.; Xu, Elvis Genbo

doi:10.1016/j.cbpc.2021.109056

Cited by 77 publications

(37 citation statements)

References 162 publications

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“…plasticizers, stabilizers, dyes, or additives) ( Sullivan et al, 2021 , Delgado-Gallardo et al, 2022 ). The toxicity mechanisms behind these responses are only studied in a few plant species and mostly investigated in case of nanoplastics as stressor (reviewed by Matthews et al 2021 ). Nevertheless, it can be assumed that compared to the effects of nanoplastics, contamination with micro- and macro-sized plastics may have different effects on the mechanisms behind the growth responses, since the uptake of micro- and especially macro-plastics is unlikely.…”

Section: Resultsmentioning

confidence: 99%

Indirect effects of COVID-19 on the environment: How plastic contamination from disposable surgical masks affect early development of plants

Mészáros

Bodor

Szierer

et al. 2022

Journal of Hazardous Materials

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Section: Resultsmentioning

confidence: 99%

Indirect effects of COVID-19 on the environment: How plastic contamination from disposable surgical masks affect early development of plants

Mészáros

Bodor

Szierer

et al. 2022

Journal of Hazardous Materials

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“…When compared to MPs and large plastic particles, NPs have distinct properties that exacerbate their toxicity. They have substantially smaller sizes (on the same scale as macromolecules and organelles), faster rates of tissue infiltration, and the ability to cross biological barriers, for example [31,32]. As discussed below, these characteristics are crucial when examining the mechanisms of toxicity and negative impacts of NPs on aquatic organisms.…”

Section: Plastics Breakdown and Small Plastic Particles: Mps And Nps ...mentioning

confidence: 99%

Nanoplastics in Aquatic Environments: Impacts on Aquatic Species and Interactions with Environmental Factors and Pollutants

Trevisan

Ranasinghe

Jayasundara

et al. 2022

Toxics

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Plastic production began in the early 1900s and it has transformed our way of life. Despite the many advantages of plastics, a massive amount of plastic waste is generated each year, threatening the environment and human health. Because of their pervasiveness and potential for health consequences, small plastic residues produced by the breakdown of larger particles have recently received considerable attention. Plastic particles at the nanometer scale (nanoplastics) are more easily absorbed, ingested, or inhaled and translocated to other tissues and organs than larger particles. Nanoplastics can also be transferred through the food web and between generations, have an influence on cellular function and physiology, and increase infections and disease susceptibility. This review will focus on current research on the toxicity of nanoplastics to aquatic species, taking into account their interactive effects with complex environmental mixtures and multiple stressors. It intends to summarize the cellular and molecular effects of nanoplastics on aquatic species; discuss the carrier effect of nanoplastics in the presence of single or complex environmental pollutants, pathogens, and weathering/aging processes; and include environmental stressors, such as temperature, salinity, pH, organic matter, and food availability, as factors influencing nanoplastic toxicity. Microplastics studies were also included in the discussion when the data with NPs were limited. Finally, this review will address knowledge gaps and critical questions in plastics’ ecotoxicity to contribute to future research in the field.

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“…As for animal/human cells, the cellular processes of NPs internalized into lysosomesis are also related to their different surface charges (Fröhlich et al, 2012;Raghnaill et al, 2014). Negative NPs can escape from lysosomes and interact with cellular components to trigger cellular stress (Wang et al, 2013;Marques-Santos et al, 2018;Matthews et al, 2021), whereas Positive NPs destabilize lysosomes and initiate a cascade of cellular damage via ROS generation due to the proton sponge hypothesis (Nel et al, 2009). Thus, the cellular process of NPs in animals and human beings might be more complicatedly affected by their charged groups.…”

Section: Toxic Mechanism Of Nanoplastics With Different Functional Group Modificationsmentioning

confidence: 99%

“…However, the formation of a PS-NH 2 -protein corona in hemolymph serum (HS) increased the short term cellular damage and ROS production of PS-NH 2 toward immunocytes (Canesi et al, 2016), because NP-protein complexes were hypothesized to function as recognizable molecular patterns to be cleared by phagocytic cells (Hayashi et al, 2013). In addition, the enhanced formation of the protein corona on positively charged NPs will promote their "Trojan-horse effect" on other pollutants (Matthews et al, 2021). The studies on the biological effects of NPs with the protein corona are still in the initial stage.…”

Section: Toxic Mechanism Of Nanoplastics With Different Functional Group Modificationsmentioning

confidence: 99%

Influence of Functional Group Modification on the Toxicity of Nanoplastics

et al. 2022

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Nanoplastics (NPs) are ubiquitous in harvested organisms at various trophic levels, and more concerns on their diverse responses and wide species-dependent sensitivity are continuously increasing. However, systematic study on the toxic effects of NPs with different functional group modifications is still limited. In this review, we gathered and analyzed the toxic effects of NPs with different functional groups on microorganisms, plants, animals, and mammalian/human cells in vitro. The corresponding toxic mechanisms were also described. In general, most up-to-date relevant studies focus on amino (−NH2) or carboxyl (−COOH)-modified polystyrene (PS) NPs, while research on other materials and functional groups is lacking. Positively charged PS-NH2 NPs induced stronger toxicity than negatively charged PS-COOH. Plausible toxicity mechanisms mainly include membrane interaction and disruption, reactive oxygen species generation, and protein corona and eco-corona formations, and they were influenced by surface charges of NPs. The effects of NPs in the long-term exposure and in the real environment world also warrant further study.

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Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups

Cited by 77 publications

References 162 publications

Indirect effects of COVID-19 on the environment: How plastic contamination from disposable surgical masks affect early development of plants

Indirect effects of COVID-19 on the environment: How plastic contamination from disposable surgical masks affect early development of plants

Nanoplastics in Aquatic Environments: Impacts on Aquatic Species and Interactions with Environmental Factors and Pollutants

Influence of Functional Group Modification on the Toxicity of Nanoplastics

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