Key genes and immune infiltration in chronic spontaneous urticaria: a study of bioinformatics and systems biology
Wenxing Su,
Yu Tian,
Yuqian Wei
et al.
Abstract:BackgroundChronic spontaneous urticaria (CSU) is defined by the spontaneous occurrence of wheals and/or angioedema for >6 weeks. The pathogenesis involves skin mast cells, but the complex causes of their activation remain to be characterized in detail.ObjectivesTo explore disease-driving genes and biological pathways in CSU.MethodsTwo microarray data sets, e.g., GSE57178 and GSE72540, with mRNA information of skin from CSU patients, were downloaded from the Gene Expression Omnibus (GEO) database. An int… Show more
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