Key functions in polymer carriers for intestinal absorption of insulin

Nakamura, Koji; Morishita, Mariko; Ehara, Junpei; Onuki, Yoshinori; Yamagata, Tetsuo; Kamei, Noriyasu; Lowman, Anthony M.; PEPPAS, N; Takayma, Kozo

doi:10.1016/j.ijpharm.2007.10.050

Cited by 13 publications

(6 citation statements)

References 22 publications

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“…Nakamura et al recently reported their findings on insulin absorption as a function of polymer properties, and developed a system, namely multivarient spline interpolation [31]. They reported that with the help of this mathematical approach, an optimized formulation was predicted, as well as how polymer function affects insulin absorption.…”

Section: Nanoparticles: a Probable Solution For Oral Insulin Deliverymentioning

confidence: 99%

“…Nakamura et al reported that the enzymatic degradation of insulin was reduced in a concentration-dependent manner with respect to the amount of polymer added [31]. They observed at least a 50% reduction in insulin degradation even with low amounts of poly methacrylic acid-g-poly ethylene glycol, which is attributed to the inhibitory effect exerted by the anionic polymer.…”

Section: Enzyme Inhibitorsmentioning

confidence: 99%

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Challenges and advances in nanoparticle-based oral insulin delivery

Rekha¹,

Sharma²

2009

Expert Review of Medical Devices

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For many decades, rigorous efforts have been made worldwide to develop a successful oral insulin-delivery system, which still remains an elusive goal. However, over the past few years, tremendous understanding has evolved in the development of biocompatible and biodegradable polymers, synthesis of nanopeptide delivery systems, biocompatibility and its cellular uptake mechanisms. With these advancements, efforts are being directed toward nanoparticle-based oral peptide-delivery systems. It is established that nanoparticles enhance oral bioavailability by facilitating insulin uptake via a transcellular or paracellular pathway. In this process, the particle also reaches the systemic circulation. Hence, biocompatibility and the half-life of the particles in the systemic circulation is an important aspect that needs to be looked into. In this review, the various approaches adopted for nanoparticle-based oral insulin delivery, uptake mechanisms, biocompatibility and bioavailability of the nanoparticle are discussed.

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Section: Nanoparticles: a Probable Solution For Oral Insulin Deliverymentioning

confidence: 99%

Section: Enzyme Inhibitorsmentioning

confidence: 99%

Challenges and advances in nanoparticle-based oral insulin delivery

Rekha¹,

Sharma²

2009

Expert Review of Medical Devices

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“…In addition, insulin denaturation has been indicated as one of the causes of failure in the preparation of insulin delivery systems [14]. Therefore, albumin coating has been indicated to avoid degradation of insulin by proteases, preventing they can reach the insulin inside the nanoparticles, giving stability to the system in the stomach [15,16].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured polymeric system based of cashew gum for oral admnistration of insulin

et al. 2019

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The subcutaneous administration of insulin has been the treatment of millions of diabetics in the world. However, for such via insulin is invasive and not mimics the physiological action causing side effects. The oral route would be the most physiological and comfortable option, but the oral bioavailability of insulin is low by proteolytic activity and reduced permeability of the gastrointestinal tract. The aim of the study was to develop a nanostructured system integrating biomaterials for oral insulin delivery. Cashew gum (CG) is a polysaccharide extracted from the exudate of the plant Anacardium occidentale. It is a biopolymer composed of simple sugars and glucuronic acid and it can be used in nanostructured systems for the incorporation of molecules. The exudate was isolated, dissolved in water, filtered, precipitated in ethanol and purified. The CG was characterized by infrared spectroscopy and molecular weight by size exclusion chromatography. Nanoparticles were prepared through ionotropic gelation integrating cashew gum, dextran sulfate and poloxamer containing insulin stabilized with chitosan, poly(ethyleneglycol) and coated with albumin. The particles were analyzed for particle size, zeta potential and insulin entrapment efficiency. The FTIR spectrum for CG showed a band at 3395 cm-1 due to the stretching vibration of O-H, a band at 2926 cm-1 of C-H vibrations; absorption at 1639 cm-1 of O-H type from bound water molecules and bands at 1143, 1073 and 1024 cm-1 due vibrations of the CO -C from glycosidic bonds and O-H of alcohols. The peak molar mass of GC was 2.35 × 10 4 g/mol. The particles had a size of 156 nm and after coating, size of 5387 nm with 92% insulin entrapment efficiency and zeta potential of-51 mV indicating electrostatic stabilization. The results suggest an innovative cashew gum base system for oral insulin administration.

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“…The aim of the present study was to assess the feasibility of formulating lipospheres of Pioglitazone HCl by melt dispersion technique and obtaining a suitable release pattern. [1][2][3][4][5] cetyl alcohol, gelatin were purchased from S.D. Fine Chemicals Ltd. (India).…”

Section: Introductionmentioning

confidence: 99%