“…The integration of data, ranging from patient records to sequencing and multi-omics technologies, as well as databases from external data sources such as drug targets, molecular pathways or clinical trials ( Figure 1 ), is a challenge that requires coordinated action at different levels. 15 , 16 , 17 The IT infrastructure to manage such data (storage, provenance, security, sharing, user interfaces and process integration) is an important element to connect research and health care provided to patients. The analysis and interpretation of data requires the development of ‘integrative workflows’, combining multiple statistical, computational and mathematical techniques in a rational and reproducible process that can be implemented in software tools.…”