Key Considerations regarding the Renal Risks of Iodinated Contrast Media: The Nephrologist’s Role

Abstract

Background. The administration of iodinated contrast medium during diagnostic and therapeutic procedures has always been associated with the fear of causing acute kidney injury (AKI) or an exacerbation of chronic kidney disease (CKD). This has led, on the one hand, to the deterrence, when possible, of the use of contrast medium (preferring other imaging methods with the risk of loss of diagnostic power), on the other hand to the trialling of multiple prophylaxis protocols in an attempt to reduce the risk of kidney injury. Summary. A literature review on contrast-induced (CI)-AKI risk mitigation strategies was performed, focusing on the recognition of individual risk factors and on the most recent evidences regarding prophylaxis. Key messages. Nephrologists can contribute significantly in CI-AKI context, from the early stages of the decision-making process by to stratifying patients by risk, individualizing prophylaxis measures based on the risk profile and ensuring appropriate evaluation of kidney function and damage post procedure to improve care.