Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D

Holers, V. Michael; Borodovsky, Anna; Scheinman, Robert I.; Ho, Nhu; Ramirez, Joseline Ramos; Dobó, József; Gál, Péter; Lindenberger, Jared; Hansen, Annette G.; Desai, Dhruv; Pihl, Rasmus; Thiel, Steffen; Banda, Nirmal K.

doi:10.3389/fimmu.2020.00201

Cited by 10 publications

(9 citation statements)

References 76 publications

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“…Interestingly, the pathway with the highest enrichment ratio (22.101) was the lectin pathway of complement activation (R-MMU-166662), which is a component of the innate immune system (Figure 32) (Ali et al, 2012). As we have seen by assessing different tissues, components of this lectin pathway of complement activation are present in all immune related tissues of the body, but are made mostly in the liver (Holers et al, 2020). The lectin pathway of complement activation is present during normal physiology in low levels to monitor for pathogens, present during sickness to recruit macrophages to the sick tissues, and present in autoimmune functions (Farrar et al, 2016).…”

Section: Network Analysesmentioning

confidence: 99%

GeneNetwork: a continuously updated tool for systems genetics analyses

Ashbrook

2020

Preprint

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GeneNetwork and its earlier iteration, WebQTL, have now been an important database and toolkit for quantitative trait genetics research for two decades. Recent improvements to GeneNetwork have reinvigorated it, including the addition of data from 10 species, multi-omics analysis, updated code, and new tools. The new GeneNetwork is now an exciting resource for predictive medicine and systems genetics, which is constantly being maintained and improved. Here, we give a brief overview of the process for carrying out some of the most common functions on GeneNetwork, as a gateway to deeper analyses, demonstrating how a small number of plausible candidate genes can be found for a typical immune phenotype.

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Section: Network Analysesmentioning

confidence: 99%

GeneNetwork: a continuously updated tool for systems genetics analyses

Ashbrook

2020

Preprint

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“…Furthermore, it was demonstrated that MASP-1 contributes to the pro-inflammatory activation of endothelial cells and increases endothelial permeability [ 82 , 83 , 84 ]. Recently, MASP-1 was reported to affect the transcription of alternative pathway factor D [ 85 ].…”

Section: Mbl-associated Serine Proteases (Masp) and Their Related mentioning

confidence: 99%

“…Moreover, it is able to activate prothrombin, and thus, participate in activation of the coagulation system (reviewed by Garred et al [ 19 ] and Pihl et al [ 20 ]) Although another MASP-2 substrate is kininogen, its cleavage does not lead to creation of bradykinin [ 16 ]. Like MASP-1, MASP-2 was recently reported to participate in the regulation of factor D transcription [ 85 ].…”

Section: Mbl-associated Serine Proteases (Masp) and Their Related mentioning

confidence: 99%

Components of the Lectin Pathway of Complement in Haematologic Malignancies

Cedzyński

Świerzko

2020

Cancers

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The complement system is activated cascadically via three distinct major routes: classical pathway (CP), alternative pathway (AP) or lectin pathway (LP). The unique factors associated with the latter are collectins (mannose-binding lectin, collectin-10, collectin-11), ficolins (ficolin-1, ficolin-2, ficolin-3) and proteins of the mannose-binding lectin-associated serine protease (MASP) family (MASP-1, MASP-2, MASP-3, MAp19, MAp44). Collectins and ficolins are both pattern-recognising molecules (PRM), reactive against pathogen-associated molecular patterns (PAMP) or danger-associated molecular patterns (DAMP). The MASP family proteins were first discovered as complexes with mannose-binding lectin (MBL) and therefore named MBL-associated serine proteases, but later, they were found to interact with ficolins, and later still, collectin-10 and collectin-11. As well as proteolytic enzymes (MASP-1, MASP-2, MASP-3), the group includes non-enzymatic factors (MAp19, MAp44). In this review, the association-specific factors of the lectin pathway with haematologic malignancies and related infections are discussed.

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“…However, a key role of MASP-1 in MASP-2 activation was established (27). It moreover enables cross-talk with the coagulation and contact systems (28,29), contributes to activation of platelets (30), endothelial cells, affects endothelial permeability (31)(32)(33), and regulates the transcription of complement factor D (34).…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

Świerzko

Cedzyński

2020

Front. Immunol.

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Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the associations of factors specific for complement activation via the lectin pathway (LP) with infections of the respiratory system, from birth to adulthood, are discussed. The most extensive data concern mannose-binding lectin (MBL) which together with other collectins (collectin-10, collectin-11) and the ficolins (ficolin-1, ficolin-2, ficolin-3) belong to patternrecognition molecules (PRM) specific for the LP. Those PRM form complexes with MBLassociated serine proteases (MASP-1, MASP-2, MASP-3) and related non-enzymatic factors (MAp19, MAp44). Beside diseases affecting humanity for centuries like tuberculosis or neonatal pneumonia, some recently published data concerning COVID-19 are summarized.

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Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D

Cited by 10 publications

References 76 publications

GeneNetwork: a continuously updated tool for systems genetics analyses

GeneNetwork: a continuously updated tool for systems genetics analyses

Components of the Lectin Pathway of Complement in Haematologic Malignancies

The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System

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