The first RF key comparison within the Inter-American Metrology System (SIM) Regional Metrology Organization has been carried out. The purpose of it was to establish the degree of equivalence of scattering parameters measurements of both 1-port and 2-port coaxial devices among national metrology institutes (NMIs) that belong to SIM region and in support of CIPM Mutual Recognition Agreement (MRA). The travelling standards were four devices with Type-N coaxial connectors and 50 Ω of characteristic impedance: a matched load, a mismatched load and two attenuators of 3 dB and 20 dB. Four SIM institutes participated in the comparison as well as NPLI.