Key Articles and Guidelines in the Management of Acute Coronary Syndrome and in Percutaneous Coronary Intervention: 2012 Update

Abstract

More than 1 million people in the United States experience an acute coronary syndrome (ACS) every year, and almost 600,000 undergo percutaneous coronary intervention (PCI) for treatment of cardiovascular disease. There is a large amount of evidence-based literature to guide appropriate management of these patients. There have been a number of advances in the treatment of these patients over the last several years. Due to the large amount of rapidly available literature concerning the care of patients with ACS or undergoing PCI, clinicians can often find it difficult to keep up with the information needed for optimizing care of these patients. Therefore, we provide the second update to the first compiled bibliography of key articles and guidelines relative to patients with ACS published in Pharmacotherapy in 2004. The initial update was published in Pharmacotherapy in 2007 and also included bibliographies concerning management of patients undergoing PCI. A number of guidelines and practice-changing literature have been published since the update in 2007. Specific areas included in this review are updated summaries of clinical practice guidelines and clinical trials of anticoagulants, antiplatelets, platelet aggregation testing, pharmacogenomics testing in patients taking clopidogrel, clopidogrel loading dose comparisons, clopidogrel and proton pump inhibitor drug interactions, the impact of bleeding in ACS, and statins. As with previous versions of this document, we hope that this compilation will serve as a resource for pharmacists, physicians, nurses, residents, and students responsible for the care of patients with coronary heart disease.

Antiplatelet Drugs

“…18 Variation in the speed and efficacy of platelet inhibition by clopidogrel has been described in humans, which may be a result of polymorphisms in hepatic P-450 enzymes and the speed of generation of the active metabolite. 18 Variation in the speed and efficacy of platelet inhibition by clopidogrel has been described in humans, which may be a result of polymorphisms in hepatic P-450 enzymes and the speed of generation of the active metabolite.…”

Key Articles and Guidelines in the Management of Dyslipidemia: 2019 Update

“…Therefore, in an attempt to highlight the most important articles, compilations of annotated bibliographies in various aspects of cardiology have been published. 1 -7 These select bibliographies are intended to serve as a resource for clinicians to quickly identify important and relevant publications that are considered the most clinically impactful within the cardiovascular (CV) literature. The concise and informative nature of these bibliographies is becoming more relevant as the breadth and depth of the cardiology literature continues to expand.…”

Key Articles and Guidelines in the Management of Hypertension

“…The Cardiology Practice and Research Network of the American College of Clinical Pharmacy has been committed to the compilation of annotated bibliographies since 2004. These focused bibliographies have been developed as a resource for health care professionals to identify up-to-date publications in various cardiovascular therapeutic areas, including, but not limited to hypertension, 1,2 acute coronary syndrome, 3 heart failure, 4 and venous thromboembolism. 5 These bibliographies have become increasingly important, given the exponential increase in clinical trials and systematic reviews in recent decades, leaving clinicians with an overload of access to unfiltered information.…”