Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies

Gupta, Ajay Kumar; Madan, Sumit; Majumdar, Dipak K.; Maitra, Amarnath

doi:10.1016/s0378-5173(00)00508-1

Cited by 145 publications

(53 citation statements)

References 23 publications

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“…Over many years research has been carried out to develop alternative novel drug delivery systems that would mimic the physiological environment by delivering insulin, in response to the blood glucose level. Formulations such as hydrogels, microcapsules, liposomes, and other soft technology systems as well as inserts and nanoparticles have been proposed (Taylor, Tanna, Taylor and Adams, 1995;Le Bourlais, Acar, Zia, Sado, Needham and Leverge, 1998;Gupta, Madan, Majumdar, and Maitra, 2000;Willoughby, Batterbury, and Kaye, 2002;Yadav, et. al., 2009;Adams, et.…”

Section: Introductionmentioning

confidence: 99%

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

Simpson

Morris

2014

Bioactive Carbohydrates and Dietary Fibre

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Diabetes is a growing global problem and a heavy financial burden on health care services. It is estimated that over 380 million people suffer from this condition which causes many deaths each year in addition to being associated with increased risk of other health problems.Traditional medicine is a promising area of research in diabetes therapy as it is widely accessible and it is believed that over 200 plants have anti-diabetic properties including members of the cucurbit family. Studies in animal and human models have shown that treatment with some cucurbits has hypoglycaemic effects and stimulates beta cell regeneration in addition to other anti-diabetic effects which are equal to that of commonly prescribed anti-diabetic drugs. It has also been shown that at least one of the bioactive components which stimulate these effects is a polysaccharide.

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Section: Introductionmentioning

confidence: 99%

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

Simpson

Morris

2014

Bioactive Carbohydrates and Dietary Fibre

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“…Polymeric micelles have been shown to be suitable ocular carriers for anti-inflammatory drugs [17] or even plasmids and genes [18,19]. Transcorneal permeation studies through excised rabbit cornea indicated that non-steroidal anti-inflammatory drug formulations in polymeric micelles can enhance about twofold drug permeation compared with that of an aqueous suspension of the same concentration because the dissolution step is overcome [17]. Recent studies have demonstrated that poloxamine micelles are able to host relatively hydrophobic drugs and to increase their apparent solubility and stability [20,21].…”

Section: Introductionmentioning

confidence: 99%

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Ribeiro

Sosnik

Chiappetta

et al. 2012

J. R. Soc. Interface.

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Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties of poloxamine (T908, T1107 and T1307) and a medium hydrophilic variety (T904), possessing a similar number of propylene oxide units but different contents in ethylene oxide, were chosen for the study. The critical micellar concentration and the cloud point of mixed micelles in 0.9 per cent NaCl were slightly greater than the values predicted from the additive rule, suggesting that the co-micellization is hindered. Micellar size ranged between 17 and 120 nm and it was not altered after the loading of ETOX (2.7-11.5 mg drug g -1 poloxamine). Drug solubilization ability ranked in the order: T904 (50-fold increase in the apparent solubility) . T1107 ffi T1307 . T908. Mixed micelles showed an intermediate capability to host ETOX but a greater physical stability, maintaining almost 100 per cent drug solubilized after 28 days. Furthermore, the different structural features of poloxamines and their combination in mixed micelles enabled the tuning of drug release profiles, sustaining the release in the 1-5 days range. These findings together with promising hen's egg test-chorioallantoic membrane biocompatibility tests make poloxamine micelles promising nanocarriers for carbonic anhydrase inhibitors in the treatment of glaucoma.

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“…All eyes were then evaluated for parameters of inflammation (i.e. lid closure extent and polymorphonuclear leukocyte (PMN) migration) (Gupta et al, 2000;Malhotra & Majumdar, 2006).…”

Section: Methodsmentioning

confidence: 99%

Glycerogelatin-based ocular inserts of aceclofenac: Physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation

Mathurm

Gilhotra

2010

Drug Delivery

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Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies

Cited by 145 publications

References 23 publications

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Glycerogelatin-based ocular inserts of aceclofenac: Physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation

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Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies

Cited by 145 publications

References 23 publications

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

The anti-diabetic potential of polysaccharides extracted from members of the cucurbit family: A review

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

Glycerogelatin-based ocular inserts of aceclofenac: Physicochemical, drug release studies and efficacy against prostaglandin E2-induced ocular inflammation

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Glycerogelatin-based ocular inserts of aceclofenac: Physicochemical, drug release studies and efficacy against prostaglandin E₂-induced ocular inflammation