Ketoreductase-assisted synthesis of chiral selective tert-butyl{5-[(4-cyanophenyl)(hydroxy)methyl]-2-fluorophenyl}carbamate: process minutiae, optimization and characterization

Khatik, Amol Gulab; Muley, Abhijeet B.; Jain, Arvind Kumar

doi:10.1007/s11696-023-02698-3

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2023

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“…Ketoreductases (KREDs) are now the main biocatalysts applied for ketone bioreduction, as well as for fluoroalkyl ketones. 9 In this context, an arsenal of enzymes from different origins is now available for the synthesis of fluoroalkyl secondary alcohols with high optical purity, including PpKR8 from Paraburkholderia phymatum , 10 CaADH from Clostridium acetobutylicum , 11 Ras-ADH from Ralstonia sp., 12 KR01 from Leifsonia sp. S749, 13 PFADH from the hyperthermophilic archaeon Pyrococcus furiosus , 14 TtADH from Thermus thermophilus , 15 SsCR from S. salmonicolor , 16 KmCR2 from K. marxianus CBS4857, 17 etc .…”

Section: Introductionmentioning

confidence: 99%