Ketoprofen-induced photoallergic dermatitis

Abstract

Drug-induced photosensitivity reactions are significant adverse effects. Ketoprofen is one of the most common drugs that can cause skin rash in sun-exposed areas. Non-steroidal anti-inflammatory drugs (NSAIDs), such as ketoprofen, are often used for a variety of symptoms, including pain and fever. An understanding of the presentation and clinical course of ketoprofen-induced photosensitivity is necessary to correctly diagnose and manage this condition. Ketoprofen-induced photosensitivity reactions usually present as photoallergic dermatitis, which is a cell-mediated immune process. The benzophenone moiety in ketoprofen plays a major role in ketoprofen's ability to act as a photosensitizer. Several agents, such as fenofibrate and octocrylene have been found to be associated with aggravation of ketoprofen-induced photoallergic dermatitis or cross-photosensitization, and these reactions result from structural similarities with ketoprofen. Treatment of ketoprofen-induced photoallergic dermatitis includes discontinuation of ketoprofen, topical or systemic corticosteroids and avoidance of sun exposure and agents known to exacerbate dermatitis. In conclusion, photoallergic dermatitis is a significant adverse effect of ketoprofen. Some agents known to worsen dermatitis may be found in sun protection products (notably, octocrylene in sunscreen). Educating the patient to avoid these products is critical to treatment. Since NSAIDs, such as ketoprofen, are used commonly for a variety of illnesses, drug-induced photoallergic dermatitis should be high on the differential in individuals using these medications who present with acute onset of a rash in sun-exposed areas.

Doxycycline-Associated Dual Cutaneous Adverse Reaction to the Drug (CARD): Case Report of Concurrent Photosensitivity and Morbilliform Exanthem to Doxycycline

“…The occurrence of these varies. The incidence of photoallergic reactions is low, and phototoxic reactions are high ( The clinical characteristics of photosensitivity drug reactions are summarized in Table 2 [1,3,[9][10][11]. Photoallergic reactions appear as eczematous lesions that can occur on both sun-exposed and non-exposed skin.…”

“…However, antibiotics can be associated with numerous side effects. These include not only systemic reactions to the medication but also cutaneous adverse reaction to the drug (CARD) [ 1 ]. Doxycycline is a tetracycline derivative.…”

Evaluation of Drug-Induced Photosensitivity Using the Japanese Adverse Drug Event Report (JADER) Database

“…[35][36][37][38] A more detailed analysis focusing on these drugs should be the subject of future investigation.…”

“…39) PTRs are dose-dependent and occur more commonly than PARs, 39) which depend on individual predisposition and involve specific immunologic reactions including antigen recognition by specific T-cells. 40) Symptoms of PARs are similar to those of contact dermatitis, and the condition is not dose-related.…”

“…40) Symptoms of PARs are similar to those of contact dermatitis, and the condition is not dose-related. PAR only occurs after an individual has already been sensitized to the agent, and typically develops within 24-72 h after exposure 39) or after multiple weeks of continuous exposure. 2,41,42) Consequently, desquamation and residual hyperpigmentation occur and can persist for more than 1 year.…”