Ketoprofen encapsulated cucurbit[6]uril nanoparticles: a new exploration of macrocycles for drug delivery

Abstract

The aim of this study is (i) to fabricate a nanoparticle formulation of ketoprofen (Keto) using a relatively new family of macrocycles as the carrier for drug delivery: cucurbit[6]uril (CB[6]), (ii) to evaluate its in vitro dissolution and (iii) to investigate its in vivo pharmaceutical property. The CB[6]–Keto nanoparticles were prepared by emulsion solvent evaporation method. Morphology and size of the successfully prepared nanoparticles were then confirmed using a transmission electron microscope and dynamic light scattering. It was shown that they are spherical with hydrodynamic diameter of 200–300 nm. The in vitro dissolution studies of CB[6]–Keto nanoparticles were conducted at pH 1.2 and 7.4. The results indicated that there is a significant increase in Keto concentration at pH 7.4 compared to pH 1.2. For the in vivo assessment, CB[6]–Keto nanoparticles and referential profenid were administered by oral gavages to rabbits. The results implied that CB[6]–Keto nanoparticles remarkably increased area under the curve compared to profenid.

Advances in Research on Biomedical Nanomaterials in Vietnam

“…Only one year 2012 eleven articles [1][2][3][4][5][6][7][8][9][10][11] have been published. In reference Ha P T et al [1] presented the results of their research on paclitaxel-loaded poly(lactide)-d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS) nanoparticles prepared by a modified solvent extraction/evaporation technique.…”

“…The authors experimentally demonstrated the ability of paclitaxel-loaded PLA-TPGS nanoparticles to induce apoptosis in human hepatocellular carcinoma cell lines (Hep-G2), indication the potential application of these nanoparticles as a cancer chemotherapeutic agent. In reference Dang M C et al [2] reported on the fabrication of a nanoparticle formulation of ketoprofen (Keto)-encapsulated cucurbit [6] (CB [6]) uril nanoparticles, the evaluation of its in vitro dissolution and the investigation of its in vivo pharmaceutical property. The CB [6]-Keto nanoparticles were prepared by emulsion solvent evaporation method.…”