Ketone bodies in cold-acclimated rats

Goubern, Marc; Cadot, M

doi:10.1016/0305-0491(83)90387-5

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Metabolism under these conditions would lead to elevated production of organic acids, such as lactic acid or ketone bodies [19][20][21]. These endogenous acids would result in an excessive acid load [22], and metabolism facilitated by ERRa may possibly exacerbate the situation.…”

Section: Introductionmentioning

confidence: 99%

“…It is noteworthy that the aforementioned conditions of high metabolic demand (in which ERRa has been implicated) are usually accompanied by the threat of acid-base disturbance. Metabolism under these conditions would lead to elevated production of organic acids, such as lactic acid or ketone bodies [19][20][21]. These endogenous acids would result in an excessive acid load [22], and metabolism facilitated by ERRa may possibly exacerbate the situation.…”

Section: Introductionmentioning

confidence: 99%

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Oestrogen-related receptor α is required for transepithelial H ⁺ secretion in zebrafish

et al. 2016

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Oestrogen-related receptor a (ERRa) is an orphan nuclear receptor which is important for adaptive metabolic responses under conditions of increased energy demand, such as cold, exercise and fasting. Importantly, metabolism under these conditions is usually accompanied by elevated production of organic acids, which may threaten the body acid-base status. Although ERRa is known to help regulate ion transport by the renal epithelia, its role in the transport of acid-base equivalents remains unknown. Here, we tested the hypothesis that ERRa is involved in acid-base regulation mechanisms by using zebrafish as the model to examine the effects of ERRa on transepithelial H þ secretion. ERRa is abundantly expressed in H þ -pump-rich cells (HR cells), a group of ionocytes responsible for H þ secretion in the skin of developing embryos, and its expression is stimulated by acidic (pH 4) environments. Knockdown of ERRa impairs both basal and low pH-induced H þ secretion in the yolk-sac skin, which is accompanied by decreased expression of H þ -secreting-related transporters. The effect of ERRa on H þ secretion is achieved through regulating both the total number of HR cells and the function of individual HR cells. These results demonstrate, for the first time, that ERRa is required for transepithelial H þ secretion for systemic acid-base homeostasis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oestrogen-related receptor α is required for transepithelial H ⁺ secretion in zebrafish

et al. 2016

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Lipids

Urich¹

1994

Comparative Animal Biochemistry

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Ambient temperature and ketone body plasma concentration in fasting geese

Cherel¹,

Jp²,

Nehlig³

et al. 1986

Pflugers Arch.

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The effect on ketonemia of alternate exposure to ambient temperatures (Ta) of 25 and 5 degrees C was investigated in fasting geese. Three experimental birds were compared to three controls continuously exposed to 25 degrees C Ta while fasting. During the first 9 days of fasting, when both groups were exposed to 25 degrees C, plasma concentration of beta-hydroxybutyrate (beta-OHB) increased similarly in both, from 0.10 +/- 0.02 to 6.62 +/- 0.71 mmol X L-1. It later plateaued at 8-9 mmol X L-1 in the control birds. When the experimental birds were exposed to 5 degrees C Ta between the 9th and 15th day of the fast, it increased further during the first 24 h but thereafter decreased of 57%, from 8.62 +/- 1.56 to 3.73 +/- 1.24 mmol X L-1. This decrease was reversed within the 6 days of return to 25 degrees C Ta. In both groups, plasma acetoacetate (AcAc) concentration remained very low during the fast: 51 +/- 1 mumol X L-1. This reversible cold-induced effect on ketonemia may be used for investigating the possible role of ketone bodies in protein sparing during fasting.

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Ketone bodies in cold-acclimated rats

Cited by 4 publications

References 13 publications

Oestrogen-related receptor α is required for transepithelial H ⁺ secretion in zebrafish

Oestrogen-related receptor α is required for transepithelial H ⁺ secretion in zebrafish

Lipids

Ambient temperature and ketone body plasma concentration in fasting geese

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Ketone bodies in cold-acclimated rats

Cited by 4 publications

References 13 publications

Oestrogen-related receptor α is required for transepithelial H + secretion in zebrafish

Oestrogen-related receptor α is required for transepithelial H + secretion in zebrafish

Lipids

Ambient temperature and ketone body plasma concentration in fasting geese

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Oestrogen-related receptor α is required for transepithelial H ⁺ secretion in zebrafish

Oestrogen-related receptor α is required for transepithelial H ⁺ secretion in zebrafish