Ketone Bodies in Acute Heart Failure: Fuel for Thought

Manla, Yosef; Kuan, William; Clark, Andrew L.; Cleland, John G.F.; Pellicori, Pierpaolo

doi:10.1016/j.cardfail.2022.11.002

Cited by 1 publication

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with HF may have increased cardiac use of ketones, but it is not clear whether the driver for consumption reflects greater accumulation and, therefore, higher myocardial availability of ketone bodies or greater myocardial avidity and preference for ketone bodies or both [ 39 , 40 ]. As mentioned, in patients with HF, ketone body plasma levels are increased and the failing heart redirects energy metabolism toward augmented use of ketone bodies at progressively higher rates, suggesting an adaptive response to stress [ 9 , 41 ].…”

Section: Ketone Bodies In Cardiovascular Diseasementioning

confidence: 99%

See 1 more Smart Citation

Ketone Bodies and Cardiovascular Disease: An Alternate Fuel Source to the Rescue

Manolis

2023

IJMS

View full text Add to dashboard Cite

The increased metabolic activity of the heart as a pump involves a high demand of mitochondrial adenosine triphosphate (ATP) production for its mechanical and electrical activities accomplished mainly via oxidative phosphorylation, supplying up to 95% of the necessary ATP production, with the rest attained by substrate-level phosphorylation in glycolysis. In the normal human heart, fatty acids provide the principal fuel (40–70%) for ATP generation, followed mainly by glucose (20–30%), and to a lesser degree (<5%) by other substrates (lactate, ketones, pyruvate and amino acids). Although ketones contribute 4–15% under normal situations, the rate of glucose use is drastically diminished in the hypertrophied and failing heart which switches to ketone bodies as an alternate fuel which are oxidized in lieu of glucose, and if adequately abundant, they reduce myocardial fat delivery and usage. Increasing cardiac ketone body oxidation appears beneficial in the context of heart failure (HF) and other pathological cardiovascular (CV) conditions. Also, an enhanced expression of genes crucial for ketone break down facilitates fat or ketone usage which averts or slows down HF, potentially by avoiding the use of glucose-derived carbon needed for anabolic processes. These issues of ketone body utilization in HF and other CV diseases are herein reviewed and pictorially illustrated.

show abstract