Ketogenic Diets and Pain

Masino, Susan A.; Ruskin, David N.

doi:10.1177/0883073813487595

Cited by 59 publications

(51 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown to have neuroprotective effects and there are now studies to determine its efficacy for a number of neurological disorders, including epilepsy, Alzheimer’s disease, Parkinson’s disease, sleep disorders, headache, traumatic brain injury, amyotrophic lateral sclerosis, pain and autism (Masino and Ruskin, 2013; Gano et al, 2014). The KD increases blood ketones and decreases blood glucose by simulating the physiological response to fasting, thus leading to high rates of fatty acid oxidation and an increase in the production of acetyl coenzyme A (acetyl-CoA).…”

Section: The Ketogenic Diet: Overview and Preclinical Evidencementioning

confidence: 99%

Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy

Woolf

Syed

Scheck

2016

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Malignant brain tumors are devastating despite aggressive treatments such as surgical resection, chemotherapy and radiation therapy. The average life expectancy of patients with newly diagnosed glioblastoma is approximately ~18 months. It is clear that increased survival of brain tumor patients requires the design of new therapeutic modalities, especially those that enhance currently available treatments and/or limit tumor growth. One novel therapeutic arena is the metabolic dysregulation that results in an increased need for glucose in tumor cells. This phenomenon suggests that a reduction in tumor growth could be achieved by decreasing glucose availability, which can be accomplished through pharmacological means or through the use of a high-fat, low-carbohydrate ketogenic diet (KD). The KD, as the name implies, also provides increased blood ketones to support the energy needs of normal tissues. Preclinical work from a number of laboratories has shown that the KD does indeed reduce tumor growth in vivo. In addition, the KD has been shown to reduce angiogenesis, inflammation, peri-tumoral edema, migration and invasion. Furthermore, this diet can enhance the activity of radiation and chemotherapy in a mouse model of glioma, thus increasing survival. Additional studies in vitro have indicated that increasing ketones such as β-hydroxybutyrate (βHB) in the absence of glucose reduction can also inhibit cell growth and potentiate the effects of chemotherapy and radiation. Thus, while we are only beginning to understand the pluripotent mechanisms through which the KD affects tumor growth and response to conventional therapies, the emerging data provide strong support for the use of a KD in the treatment of malignant gliomas. This has led to a limited number of clinical trials investigating the use of a KD in patients with primary and recurrent glioma.

show abstract

Section: The Ketogenic Diet: Overview and Preclinical Evidencementioning

confidence: 99%

Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy

Woolf

Syed

Scheck

2016

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…can alleviate neuropathic pain ( 14,176 ). Additionally, ASDs are often prescribed for chronic pain, further suggesting similarities in the pathophysiology of these two disorders ( 177 ). In juvenile and adult rats, the KD reduced pain, as assessed by increased latency to hind-paw withdrawal in a test of thermal nociception, and infl ammation, as measured by hind-paw swelling in response to injection of the immune-potentiator, Freund's complete adjuvant ( 176 ).…”

Section: Pain and Infl Ammationmentioning

confidence: 99%

Ketogenic diets, mitochondria, and neurological diseases

Gano

Patel

Rho

2014

Journal of Lipid Research

213

193

View full text Add to dashboard Cite

“…Moreover, participants reported improvements in a variety of health conditions after initiating a low-carbohydrate diet, some of which have been studied before, at least preliminarily (improvements in symptoms related to migraines, 116 irritable bowel syndrome, 117 heartburn, 118 polycystic ovary syndrome, 119 NAFLD 120 and pain 121 ), and some of which have not been studied well or much at all (e.g., libido, immune function and allergies). More research is needed on these topics.…”

mentioning

confidence: 99%

A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal

Cucuzzella

Tondt

Dockter

et al. 2017

JMH

View full text Add to dashboard Cite

Background: Metabolic syndrome has become a significant problem, with the American Diabetes Association estimating the cost of diabetes and pre-diabetes in the United States alone to be $322 billion per year. Numerous clinical trials have demonstrated the efficacy of low-carbohydrate diets in reversing metabolic syndrome and its associated disorders.Aim: This study was designed to examine how voluntary adherents to a low-carbohydrate diet rate its effectiveness and sustainability using an online survey.Setting and methods: The 57-question survey was administered online and shared internationally via social media and ‘low-carb’ communities. Where appropriate, chi-squared tests and paired t-tests were used to analyse the responses.Results: There were 1580 respondents. The majority of respondents had consumed less than 100 g of carbohydrates per day for over a year, typically for reasons of weight loss or disease management. There was a reported decrease in waist circumference and weight with a simultaneous decrease in hunger and increase in energy level. Of those who provided laboratory values, the majority saw improvements in their HbA1c, blood glucose measurements, and lipid panel results. There was a reduction in usage of various medications, and 25% reported medication cost savings, with average monthly savings of $288 for those respondents. In particular, the usage of pain relievers and anti-inflammatories dropped with a simultaneous decreased rating of pain and increase in mobility.Conclusion: We conclude that low-carbohydrate diets are a sustainable method of metabolic syndrome reversal in a community setting.

show abstract

Ketogenic Diets and Pain

Cited by 59 publications

References 67 publications

Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy

Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy

Ketogenic diets, mitochondria, and neurological diseases

A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal

Contact Info

Product

Resources

About