Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice

Tozzi, Rossella; Campolo, Federica; Baldini, Enke; Venneri, Mary Anna; Lubrano, Carla; Ulisse, Salvatore; Gnessi, Lucio; Mariani, Stefania

doi:10.3390/ijms232415860

Cited by 6 publications

(2 citation statements)

References 85 publications

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“…One exception is a study in the model of Dravet syndrome where increased calorie intake was accompanied by increased body weight probably resulting from improvement of other disease symptoms ( 44 ). Decreased calorie intake, accompanied by decreased body weight during nutritional ketosis was reported in a couple of studies ( 53 , 159 – 163 ). Taken together the majority of studies show that a KD, in comparison to standard chow, does not induce a spontaneous reduction in food intake.…”

Section: Behavioral Effects Of Kd Treatmentmentioning

confidence: 85%

Ketogenic diet and behavior: insights from experimental studies

Grabowska,

Grabowski,

Przybyła

et al. 2024

Front. Nutr.

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As a journal page for full details. The ketogenic diet (KD) has been established as a treatment for epilepsy, but more recently it has been explored as an alternative or add-on therapy for many other diseases ranging from weight loss to neurological disorders. Animal models are widely used in studies investigating the therapeutic effects of the KD as well as underlying mechanisms. Especially in the context of neurological, psychiatric, and neurodevelopmental disorders essential endpoints are assessed by behavioral and motor tests. Here we summarized research evaluating the influence of the KD on cognition, depressive and anxiety-related behaviors, and social and nutritional behaviors of laboratory rodents. Each section contains a brief description of commonly used behavioral tests highlighting their limitations. Ninety original research articles, written in English, performed on mice or rats, providing measurement of blood beta-hydroxybutyrate (BHB) levels and behavioral evaluation were selected for the review. The majority of research performed in various disease models shows that the KD positively impacts cognition. Almost an equal number of studies report a reduction or no effect of the KD on depressive-related behaviors. For anxiety-related behaviors, the majority of studies show no effect. Despite the increasing use of the KD in weight loss and its appetite-reducing properties the behavioral evaluation of appetite regulation has not been addressed in preclinical studies. This review provides an overview of the behavioral effects of nutritional ketosis addressed to a broad audience of scientists interested in the KD field but not necessarily specializing in behavioral tests.

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Section: Behavioral Effects Of Kd Treatmentmentioning

confidence: 85%

Ketogenic diet and behavior: insights from experimental studies

Grabowska,

Grabowski,

Przybyła

et al. 2024

Front. Nutr.

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“…Considering the low efficiency of the growth factor to stimulate the growth of colon cancer cells, the supplementation of a ketogenic diet is potential adjuvant therapy for colon cancer. The progression of colon cancer is systemic inflammation [30]. It has been reported that the ketogenic diet metabolite of the ketone body specifically β-hydroxybutyrate and acetoacetate acid can directly suppress co-lon cancer inflammation [31].…”

Section: American Journal Of Biomedical Science and Researchmentioning

confidence: 99%

The Ketogenic Diet Intervention in Obesity-Associated Colon Cancer Risk Reduction

2023

AJBSR

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Colon cancer causes morbidity and mortality. Many reviews have suggested that ketogenic diet intervention is associated with obesity and a higher risk of colon cancer. Is currently unknown comprehensive data from the literature review available from respective journals on ketogenic dietary intervention in obesity-associated colon cancer risk reduction. People with obesity may be able to reduce their risk of colorectal cancer with weight loss medication. The ketogenic dietary modification may have the ability to protect against the early prevention of colon cancer. There are many factors that lead to obesity-associated colon cancer risk reduction and the ketogenic dietary mechanisms behind it are still undergoing intensive weight loss interventions. This review aims to report on obesity-associated colorectal cancer and the beneficial effects of the ketogenic diet to reduce the risk of obesityassociated colorectal cancer.

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Ketogenic Diets Hold Therapeutic Potential Against Periodontal Inflammation

Karmakar,

Shivaprasad,

Arangaraju

et al. 2024

Curr Oral Health Rep

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Purpose of Review Periodontitis, one of the most prevalent diseases in the world, is caused by the accumulation of dysbiotic microbial biofilm on the teeth leading to chronic inflammation of the tissues surrounding the teeth. Type 2 diabetes mellitus (T2DM), obesity, chronic stress, and smoking are some of the risk factors for the disease. A high-carbohydrate diet also increases the risk of periodontal inflammation. Modifying diet and nutrition could serve as a preventive and therapeutic tool to target multiple risk factors simultaneously. Recent Findings Emerging evidence shows that the ketogenic diet induces hormetic stress and switches on various cell-protective anti-inflammatory and antioxidant mechanisms. The ketogenic diet also improves mitochondrial function, DNA repair, and autophagy. The diet can effectively treat periodontitis risk factors such as T2DM and obesity. By restricting carbohydrates, the diet improves glycaemic control in T2DM patients and can effectively produce fat loss and reduce BMI (body-mass index) in obese patients. Poor long-term compliance and high cost are the drawbacks of the diet and the potential of the diet to increase cardiovascular disease risk needs further investigation. Summary Taken together, ketogenic diets, through various mechanisms reduce inflammation, mitigate oxidative stress, improve metabolic health, and can be used as a therapeutic tool to treat periodontal inflammation. Since robust scientific evidence for the ketogenic diet is currently scarce, future research should study the diet's efficacy, effectiveness, and safety in managing periodontal inflammation.

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Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice

Cited by 6 publications

References 85 publications

Ketogenic diet and behavior: insights from experimental studies

Ketogenic diet and behavior: insights from experimental studies

The Ketogenic Diet Intervention in Obesity-Associated Colon Cancer Risk Reduction

Ketogenic Diets Hold Therapeutic Potential Against Periodontal Inflammation

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