Ketogenic diet in migraine treatment: A brief but ancient history

Maggioni, Ferdinando; Margoni, Monica; Zanchin, Giorgio

doi:10.1177/0333102411412089

Cited by 32 publications

(16 citation statements)

References 9 publications

(11 reference statements)

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“…A randomized crossover study of 42 adults with migraine found a low-fat vegan diet was more effective than a placebo supplement in improving headache severity during the study period (56). Ketogenic diets may improve migraine based on a few small case series in adults and children, but compliance can be difficult (57). In patients with irritable bowel syndrome and migraine, food elimination based on IgG antibodies may improve migraine frequency as well as bowel symptoms (58).…”

Section: Dietary Triggers In Migrainementioning

confidence: 99%

Triggers, Protectors, and Predictors in Episodic Migraine

Marmura

2018

Curr Pain Headache Rep

119

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Section: Dietary Triggers In Migrainementioning

confidence: 99%

Triggers, Protectors, and Predictors in Episodic Migraine

Marmura

2018

Curr Pain Headache Rep

119

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“…Some have suggested a low fat or a low protein diet, 73,74 while others have suggested a high fat or a low carbohydrate diet as possible migraine preventative therapy. 75,76 However, all such studies have been either negative or methodologically flawed preventing conclusions. Thus, we remain without definitive scientific evidence substantiating the efficacy of any particular diet as a part of migraine therapy.…”

Section: Treatment Considerations For Overweight and Obese Headache Pmentioning

confidence: 99%

Obesity and Headache: Part II – Potential Mechanism and Treatment Considerations

et al. 2014

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Obesity and headache are both associated with a substantial personal and societal impact, and epidemiologic studies have consistently identified a positive association between obesity and headache in general, as well as obesity and migraine specifically (see part I). In the current manuscript, we will discuss the potential mechanisms for the migraine–obesity association, with a focus on the central and peripheral pathophysiological pathways which overlap between migraine and those modulating the drive to feed. We then discuss surgical, behavioral, and pharmacological treatment considerations for overweight and obese migraineurs as well as for those with idiopathic intracranial hypertension. We close by briefly discussing where future research may be headed in light of this data.

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“…Further support for a link to energy metabolism and / or mitochondrial functioning comes from the migraine preventative effect of several nutraceuticals (22), such as riboflavin at high dose (200-400mg/ day) (23)(24)(25)(26)(27)(28)(29); coenzyme Q10 (400mg capsules or 300mg liquid suspension) (30)(31)(32)(33)(34)(35), magnesium (36) and alpha-lipoic acid (ALA; 600mg) (37)(38)(39). Dietary approaches, such as a ketogenic diet (KD), which promotes the hepatic production of an alternative energy substrate for the brain and to some extent mimics the state of fasting, have been shown to be migraine protective (40)(41)(42)(43)(44)(45) (see (46) for potential mechanism of ketosis in migraine). Moreover, elevated plasma lactate and pyruvate levels have been reported, but mostly in severely affected patients, such as migrainous stroke (47,48).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

Gross

Putananickal²,

Orsini³

et al. 2020

Preprint

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Introduction Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function / oxidative stress markers have not yet been examined. Methods To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5-14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study. Results The majority of patients had abnormally low ALA and lactate levels (87.5% and 78.1%, respectively). 46.9% of the patients had abnormally high PerOx values, while for thiols and TAC over one third of patients had abnormally low values (31.2% and 37.5%, respectively). 21.9% of patients had abnormally low HbA1c and none had an HbA1c level above 5.6%. oxLDL was normal in all but one patient. Discussion This study provides further evidence for a role of oxidative stress and altered metabolism in migraine pathophysiology, which might represent a suitable therapeutic target. ALA, being too low in almost 90% of patients, might represent a potential biomarker for migraine. Further research is needed to replicate these results, in particular a comparison with a control group. This study is part of the trial registration: ClinicalTrials.gov: NCT03132233, registered on 27.04.2017, https://clinicaltrials.gov/ct2/show/NCT03132233

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Ketogenic diet in migraine treatment: A brief but ancient history

Cited by 32 publications

References 9 publications

Triggers, Protectors, and Predictors in Episodic Migraine

Triggers, Protectors, and Predictors in Episodic Migraine

Obesity and Headache: Part II – Potential Mechanism and Treatment Considerations

Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

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