Ketogenic diet in clinical practices

Çağıran, İbrahim Hakkı; Yılmaz, Dursun Alper

doi:10.1016/j.hnm.2024.200250

Cited by 1 publication

(1 citation statement)

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“…Ensuring a healthy dietary fatty acid profile (mono-and polyunsaturated fatty acids, while avoiding saturated and transunsaturated fatty acids) and cooking techniques (cooking, grilling, and baking instead of frying) minimizes the risk of hypercholesterolemia. The carbohydrate restriction leads to a low amount of fiber in the diet and could lead to constipation [147]. The fiber also positively affects lipid metabolism.…”

Section: A Practical Guide To Using the Kd In Psychiatric Disordersmentioning

confidence: 99%

The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice

Rog,

Wingralek,

Nowak

et al. 2024

JCM

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The ketogenic diet (KD) is a high-fat, low-carbohydrate diet that mimics the physiological state of fasting. The potential therapeutic effects in many chronic conditions have led to the gaining popularity of the KD. The KD has been demonstrated to alleviate inflammation and oxidative stress, modulate the gut microbiota community, and improve metabolic health markers. The modification of these factors has been a potential therapeutic target in serious mental illness (SMI): bipolar disorder, major depressive disorder, and schizophrenia. The number of clinical trials assessing the effect of the KD on SMI is still limited. Preliminary research, predominantly case studies, suggests potential therapeutic effects, including weight gain reduction, improved carbohydrate and lipid metabolism, decrease in disease-related symptoms, increased energy and quality of life, and, in some cases, changes in pharmacotherapy (reduction in number or dosage of medication). However, these findings necessitate further investigation through larger-scale clinical trials. Initiation of the KD should occur in a hospital setting and with strict care of a physician and dietitian due to potential side effects of the diet and the possibility of exacerbating adverse effects of pharmacotherapy. An increasing number of ongoing studies examining the KD’s effect on mental disorders highlights its potential role in the adjunctive treatment of SMI.

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Section: A Practical Guide To Using the Kd In Psychiatric Disordersmentioning

confidence: 99%