Ketogenic Diet in Advanced Cancer: A Pilot Feasibility and Safety Trial in the Veterans Affairs Cancer Patient Population

Tan-Shalaby, Jocelyn; Seyfried, Thomas N.

doi:10.4172/2167-0870.1000149

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Tan-Shalaby et al examined the impact of the modified Atkins diet on cancer development. A total of 17 patients with advanced cancer, who had not undergone chemotherapy, were enrolled for the study (29). They received 20 g–40 g of carbohydrates daily for 16 weeks and were assessed every 4 weeks.…”

Section: Dietary Carbohydrate and Cancermentioning

confidence: 99%

Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level

Doaei

Akbari

et al. 2019

MJMS

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Cancer cells are mainly dependent on glycolysis for their growth and survival. Dietary carbohydrates play a critical role in the growth and proliferation of cancer and a low-carbohydrate diet may help slow down the growth of tumours. However, the exact mechanisms behind this effect are unclear. This review study aimed to investigate the effect of fat mass and obesity-associated (FTO) gene in the association between dietary carbohydrates and cancer. This study was carried out using keywords such as polymorphism and/or cancer and/or dietary carbohydrate and/or FTO gene. PubMed and Science Direct databases were used to collect all related articles published from 1990 to 2018. Recent studies showed that the level of FTO gene expression in cancer cells is dramatically increased and may play a role in the growth of these cells through the regulation of the cellular metabolic pathways, including the phosphoinositide 3-kinases/protein kinaseB (PI3K/AKT) signaling pathway. Dietary carbohydrate may influence the FTO gene expression by eliminating the inhibitory effect of adenosine monophosphate-activated protein kinase (AMPK) on the FTO gene expression. This review summarised what has been recently discovered about the effects of dietary carbohydrate on cancer cells and tried to determine the mediating role of the FTO gene in these effects.

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Section: Dietary Carbohydrate and Cancermentioning

confidence: 99%

Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level

Doaei

Akbari

et al. 2019

MJMS

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“…A therapeutic weight plateau should follow initial weight loss with KD, in contrast to pathologic rapid weight loss in non-KD patients. 9 Kidney stones, gout, and symptomatic hypoglycemia were also potential expected adverse effects (AEs).…”

Section: Ketogenic Diet Benefitsmentioning

confidence: 99%

Ketogenic Diets and Cancer: Emerging Evidence

Tan-Shalaby

2017

Federal Practitioner

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Starvation of cancer via induced ketogenesis and severe hypoglycemia

Kapelner

Vorsanger

2015

Medical Hypotheses

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Neoplasms are highly dependent on glucose as their substrate for energy production and are generally not able to catabolize other fuel sources such as ketones and fatty acids. Thus, removing access to glucose has the potential to starve cancer cells and induce apoptosis. Unfortunately, other body tissues are also dependent on glucose for energy under normal conditions. However, in human starvation (or in the setting of diet-induced ketogenesis), the body "keto-adapts" and glucose requirements of most tissues drop to almost nil. Exceptions include the central nervous system (CNS) and various other tissues which have a small but obligatory requirement of glucose. Our hypothesized treatment takes keto-adaptation as a prerequisite. We then propose the induction of severe hypoglycemia by depressing gluconeogenesis while administering glucose to the brain. Although severe hypoglycemia normally produces adverse effects such as seizure and coma, it is relatively safe following keto-adaptation. We hypothesize that our therapeutic hypoglycemia treatment has potential to rapidly induce tumor cell necrosis.

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Ketogenic Diet in Advanced Cancer: A Pilot Feasibility and Safety Trial in the Veterans Affairs Cancer Patient Population

Cited by 3 publications

References 16 publications

Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level

Dietary Carbohydrate Promotes Cell Survival in Cancer Via the Up-Regulation of Fat Mass and Obesity-Associated Gene Expression Level

Ketogenic Diets and Cancer: Emerging Evidence

Starvation of cancer via induced ketogenesis and severe hypoglycemia

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