Ketogenic diet attenuates spatial and item memory impairment in pentylenetetrazol-kindled rats

Jiang, Yan; Lu, Yu-Qiang; Jia, Mengmeng; Wang, Xiaohang; Zhang, Zhengxiang; Hou, Qun; Wang, Baohui

doi:10.1016/j.brainres.2016.06.029

Cited by 22 publications

(26 citation statements)

References 28 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[2][3][4] Although a host of neuroimaging studies have investigated brain networks in TLE patients, 2-6 studies on medical and surgical treatments as well as the underlying mechanisms in animal models are urgently needed due to ethical concerns. A number of models have been used to induce epilepsy in rodents, [7][8][9] for example, systemic or nuclear administration of chemicals. Among these models, systemic administration of lithium-pilocarpine (LIP) is frequently used, because it can reproduce most clinical and neuropathological features of human TLE.…”

Section: Introductionmentioning

confidence: 99%

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

et al. 2018

View full text Add to dashboard Cite

Our results indicated a trend of decreased connectivity in the hippocampal functional network, as well as spatial, object, and episodic memory impairment in the pilocarpine-induced TLE rat. Moreover, connections within the hippocampal network showed a relationship with spatial memory, and connections between the hippocampal network and regions in other networks revealed an association with both spatial and object memory.

show abstract

Section: Introductionmentioning

confidence: 99%

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…For example, Ijff et al found that the KD exerts a positive impact on behavior and cognitive functioning in children and adolescents with refractory epilepsy [7]. In a rat epilepsy model kindled with pentylenetetrazol, KD not only attenuated the decrease in the exploration ratio in both the new object recognition and novel placement recognition task but also had a protective effect on spatial memory in the Morris water maze [8]. Although increasing evidence that the KD enhances cognitive function in both pathophysiological and normal healthy experimental animal systems [9,10], the exact mechanism of action by which the KD exerts these effects has not been fully understood.…”

Section: Introductionmentioning

confidence: 99%

Ketogenic diet improves the spatial memory impairment caused by exposure to hypobaric hypoxia through increased acetylation of histones in rats

et al. 2017

View full text Add to dashboard Cite

Exposure to hypobaric hypoxia causes neuron cell damage, resulting in impaired cognitive function. Effective interventions to antagonize hypobaric hypoxia-induced memory impairment are in urgent need. Ketogenic diet (KD) has been successfully used to treat drug-resistant epilepsy and improves cognitive behaviors in epilepsy patients and other pathophysiological animal models. In the present study, we aimed to explore the potential beneficial effects of a KD on memory impairment caused by hypobaric hypoxia and the underlying possible mechanisms. We showed that the KD recipe used was ketogenic and increased plasma levels of ketone bodies, especially β-hydroxybutyrate. The results of the behavior tests showed that the KD did not affect general locomotor activity but obviously promoted spatial learning. Moreover, the KD significantly improved the spatial memory impairment caused by hypobaric hypoxia (simulated altitude of 6000 m, 24 h). In addition, the improving-effect of KD was mimicked by intraperitoneal injection of BHB. The western blot and immunohistochemistry results showed that KD treatment not only increased the acetylated levels of histone H3 and histone H4 compared to that of the control group but also antagonized the decrease in the acetylated histone H3 and H4 when exposed to hypobaric hypoxia. Furthermore, KD-hypoxia treatment also promoted PKA/CREB activation and BDNF protein expression compared to the effects of hypoxia alone. These results demonstrated that KD is a promising strategy to improve spatial memory impairment caused by hypobaric hypoxia, in which increased modification of histone acetylation plays an important role.

show abstract

“…(). KD treatment is a relatively safe treatment method, which can play a role in cognitive and motor function of children, and a large number of tests have confirmed that KD can control the onset of pharmacoresistant epileptic encephalopathy and improve cognition, which may be reflect a reduction in memory impairment caused by seizures in KD‐treated children (Jiang et al., ). The mechanism underlying KD treatment may be related to neuroprotection (Hallböök, Ji, Maudsley, & Martin, ), a reduction in clinical seizure activity, improved energy metabolism, and a reduction in stress‐induced biochemical effects within the hippocampus, thus improving the internal environment and improving cognitive and behavioral function (Brownlow, Jung, Moore, Bechmann, & Jankord, ).…”

Section: Discussionmentioning

confidence: 99%

Ketogenic diet effects on 52 children with pharmacoresistant epileptic encephalopathy: A clinical prospective study

Wang

Fan

et al. 2018

Brain and Behavior

View full text Add to dashboard Cite

ObjectiveTo evaluate the clinical impact of ketogenic diet (KD) on children with pharmacoresistant epileptic encephalopathy.MethodsIn all, 52 children with pharmacoresistant epileptic encephalopathy that diagnosed in our hospital from July 2012 to June 2015 were selected, including West syndrome 38 cases, Lennox–Gastaut Syndrome 7 cases, Doose Syndrome 1 case, and Dravet syndrome 6 cases, and the effect, compliance, adverse reactions, electroencephalogram (EEG), and cognitive function were analyzed. Modified Johns Hopkins protocol was used to initiate KD, and Engel scale was used to evaluate the effect, and evaluated the effect of KD on the cognition, language, and motor function.ResultsAt 12 weeks of KD treatment, the patients achieved I, II, III, and IV grade effect were accounted for 26.9% (14/52 cases), 17.3% (9/52 cases), 11.5% (6/52 cases), and 44.2% (23/52 cases), respectively, according to Engel scale. KD has different effect on different epileptic syndromes, best effect on Doose syndromes of 100%, and better effect on West syndrome with the effect rate of 57.9%, and the total effect number was 22 cases. The reduction of epileptiform discharges in the awake state before KD treatment was correlated with the seizure time after 3 months of KD treatment (r = .330, p = .017). The cognitive function of 23 patients was improved, 12 patients had language improvement, and the motor function was improved in 10 patients. In all, 23 patients had adverse reactions, and all patients were tolerated and improved.Conclusion KD has certain effect on children with pharmacoresistant epileptic encephalopathy, and it can reduce interictal epileptic discharge frequency, and improve the background rhythm of EEG. The reduction of epileptiform discharges in awake state is in favor of the reduction of seizures frequency, thus increasing the efficacy, and improve the cognitive function, language, and motor function to varying degrees, combined with less adverse reaction, which is worthy of clinical application.

show abstract

Ketogenic diet attenuates spatial and item memory impairment in pentylenetetrazol-kindled rats

Cited by 22 publications

References 28 publications

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

Abnormal hippocampal functional network and related memory impairment in pilocarpine‐treated rats

Ketogenic diet improves the spatial memory impairment caused by exposure to hypobaric hypoxia through increased acetylation of histones in rats

Ketogenic diet effects on 52 children with pharmacoresistant epileptic encephalopathy: A clinical prospective study

Contact Info

Product

Resources

About