Ketenes as Privileged Synthons in the Synthesis of Heterocyclic Compounds Part 3

Heravi, Majid Μ.; Talaei, Bahareh

doi:10.1016/bs.aihch.2015.10.007

Cited by 42 publications

(6 citation statements)

References 295 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] In recent years, our group has also focused on the applications of name reactions in the total synthesis of natural products containing nitrogen heterocycles, showing diverse biological activities.…”

Section: Introductionmentioning

confidence: 99%

“…[25][26][27][28][29][30][31][32][33] We are interested in heterocyclic chemistry, 24 especially those containing nitrogen atom. [25][26][27][28][29][30][31][32][33] In recent years, our group has also focused on the applications of name reactions in the total synthesis of natural products containing nitrogen heterocycles, showing diverse biological activities. [34][35][36][37][38][39][40][41][42] Armed with these experiences, in this review we try to highlight the medical usages and selected synthetic pathways of approved and market purchasable prescribed medications, containing nitrogen based-heterocycles.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prescribed drugs containing nitrogen heterocycles: an overview

2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prescribed drugs containing nitrogen heterocycles: an overview

2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…In 2015, the importance and diversity of post-Ugi-4CRs for the construction of a divergently oriented heterocyclic systems has been extensively reviewed [12]. We are interested in heterocyclic chemistry [36][37][38][39][40][41][42][43][44][45] and reported the synthesis of several heterocyclic systems via MCRs [46][47][48][49][50][51][52][53]. We have also recently reported the synthesis of various heterocyclic systems via the appropriate post-Ugi-adducts reaction [54][55][56][57][58].…”

Section: Introductionmentioning

confidence: 99%

Highly regio- and diastereoselective synthesis of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles, based on a post-Ugi condensation: joint experimental and computational study

et al. 2019

Self Cite

View full text Add to dashboard Cite

A novel series of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles were synthesized via a two-step pathway. In the first step, Ugi-four-component condensation of 2-formylindole, amines, (E)-4-alkoxy-4-oxobut-2-enoic acids, and isocyanides gave the corresponding Ugi-adducts. This adduct underwent intramolecular hydroamination in the presence of K 2 CO 3 in CH 3 CN at room temperature to afford diastereoselective synthesis of a range of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles. A comparison of experimentally observed CD and UV-visible spectra with the theoretical DFT calculated ECD spectra was used to predict the major diastereomer.

show abstract

“…We are interested in heterocyclic chemistry and their asymmetric synthesis . We have recently reviewed the applications of DA and HDA reactions in the total synthesis of natural products ,.…”

Section: Introductionmentioning

confidence: 99%

Applications of Dainshefsky's Dienes in the Asymmetric synthesis of Aza‐Diels‐Alder Reaction

Koshvandi

Heravi

2018

The Chemical Record

Self Cite

View full text Add to dashboard Cite

Asymmetric hetero-Diels-Alder (AHDA) reactions provide a multitude of opportunities for the highly efficient, regio- and stereoselective construction of various heterocycles in enantiomerically pure form. The asymmetric aza-Diels-Alder (A-aza-DA) reaction using diversely hetero-dienophiles and hetero-dienes have been increasingly developed as a valuable method for the synthesis of functionalized nitrogen ring systems. The purpose of this review is to give a detailed discussion of the A-aza-DA reaction particularly, the stereoselective reactions of imines as dienophiles with Dainshefsky dienes to obtain optically pure aza-Diels-Alder products. The development of stereoselective variants of the reaction make use of imines as the dienophile and Dainshefsky dienes is at the forefront of these studies. This review updates the A-aza-DA reactions covering the literature from 1972 till date.

show abstract

Ketenes as Privileged Synthons in the Synthesis of Heterocyclic Compounds Part 3

Cited by 42 publications

References 295 publications

Prescribed drugs containing nitrogen heterocycles: an overview

Prescribed drugs containing nitrogen heterocycles: an overview

Highly regio- and diastereoselective synthesis of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles, based on a post-Ugi condensation: joint experimental and computational study

Applications of Dainshefsky's Dienes in the Asymmetric synthesis of Aza‐Diels‐Alder Reaction

Contact Info

Product

Resources

About