Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation

Peiró, Ana M.; Climent, L.; Zapater, Pedro; Horga, A.; Horga, J.F.

doi:10.1016/j.phrs.2011.02.009

Cited by 2 publications

(1 citation statement)

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“…The study indicated that long-lasting antinociception was completely blocked by the 5-HT 2A receptor antagonists, Ketanserin [ 27 ]. Peiró et al reported 5-HT inhibition of the kappa-opioid component of morphine antinociceptive effects and the possibility that this serotonergic inhibition could be reversed through 5-HT2 receptor antagonist Ketanserin [ 28 ]. Crisp et al reported that intrathecal administration of 5-HT agonist, 8-OH-DPAT produced hyperalgesia with the tail-flick test and analgesia with the hot-plate test, and 5-HT 1B agonist, TFMPP, 5-HT 2A agonist and DOI phenylbiguanide produced analgesia with the hot-plate test in the rat [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Study on the Antinociceptive Effects of Herba Epimedium in Mice

Sun

Ruan

Wang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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The present study was conducted to investigate the antinociceptive action of relationship between Herba Epimedium (HE) and 5-HT1A receptor, between Herba Epimedium (HE) and 5-HT2A receptor. We used the hot-plate method and the writhing assay in mice by the intracerebroventricular (i.c.v.) injection and observed the analgesic effect of HE. Furthermore, through the i.c.v. injection, 5-HT1A receptor partial agonist Buspirone, antagonist Propranolol, the adrenaline β 1-receptor selective blocking agent Metoprolol, and 5-HT2A receptor agonist hydrochloride DOI and antagonist Ketanserin were used, and, 5 min later, HE was used to investigate the impacts of drugs on the analgesic effect in the same way. Results showed that HE had fast and significant antinociception in nervous system, and the effects can persist for a long time. Buspirone and Hydrochloride DOI can remarkably increase the antinociception of HE in nervous system. Ketanserin leads to a significant decrease in its antinociception in nervous system; Metoprolol also has antinociceptive action in nervous system, but it can inhibit the antinociceptive effect of Herba Epimediumin peripheral region. These results suggest that HE has significant antinociception effect and its mechanism is related with 5-HT1A receptor, 5-HT2A receptor, and adrenaline β 1-receptor.

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Section: Discussionmentioning

confidence: 99%