Ketamine potentiates the responses of the rat superior cervical ganglion to GABA

Lack of Correlation Between the Anaesthetic and Anti-Convulsant Potencies of Althesin, Ketamine and Methohexitone

“…Thus ketamine failed to lower the minimum electroshock seizure threshold in mice [16], and there was only an insignificant effect of ketamine on strychnine-induced seizures in mice [17]. In neurochemical studies it has been shown that ketamine potentiated the effects of GABA at its receptor site [18]. Accumulation of GABA in the synaptic cleft has been proposed as a possible mechanism of action for the anaesthetic/anticonvulsant properties of ketamine [19].…”

The effects of benzodiazepine agonists, inverse agonists and Ro 15–1788 on the responses of the superior cervical ganglion to GABA in vitro

“…As described in the Results, desensitization complicates the interpretation of these curves but it is apparent that PCCM did not decrease the maximum responses nor did chlordiazepoxide increase them. (It is possible to increase the maximum responses to GABA on this preparation, for example with ketamine; Little & Atkinson, 1983).…”

S‐ketamine and GABA‐A‐receptor interaction in humans: an exploratory study with I‐123‐iomazenil SPECT

“…It has been demonstrated that GABA-A antagonism can influence the anaesthetic potency of ketamine (Sonner et al, 2003). In vitro experiments suggested that ketamine may increase GABAmediated inhibition and thus act as a GABA-mimetic (Gage and Robertson, 1985;Liske et al, 1990;Little and Atkinson, 1984;Scholfield, 1980).…”