Ketamine modulates neural stem cell differentiation by regulating TRPC3 expression through the GSK3β/β-catenin pathway

She, Ying-Jun; Jiang, Pan; Peng, Liangming; Ma, Li; Guo, Xinying; Lei, Dong-Xu; Wang, Huai-Zhen

doi:10.1016/j.neuro.2022.10.018

Cited by 1 publication

(1 citation statement)

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“…This reveals that TRPC3 is required for both early and late neural differentiation [153]. Moreover, it has recently been reported that the increased neuron differentiation of NSCs by ketamine is due to dramatic repression of the expression of TRPC3, partly by regulating the Glycogen synthase kinase 3β (GSK3β)/βcatenin pathway [172].…”

Section: Trpcsmentioning

confidence: 90%

Calcium and Neural Stem Cell Proliferation

Díaz-Piña,

Rivera-Ramírez,

García-López

et al. 2024

IJMS

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Intracellular calcium plays a pivotal role in central nervous system (CNS) development by regulating various processes such as cell proliferation, migration, differentiation, and maturation. However, understanding the involvement of calcium (Ca2+) in these processes during CNS development is challenging due to the dynamic nature of this cation and the evolving cell populations during development. While Ca2+ transient patterns have been observed in specific cell processes and molecules responsible for Ca2+ homeostasis have been identified in excitable and non-excitable cells, further research into Ca2+ dynamics and the underlying mechanisms in neural stem cells (NSCs) is required. This review focuses on molecules involved in Ca2+ entrance expressed in NSCs in vivo and in vitro, which are crucial for Ca2+ dynamics and signaling. It also discusses how these molecules might play a key role in balancing cell proliferation for self-renewal or promoting differentiation. These processes are finely regulated in a time-dependent manner throughout brain development, influenced by extrinsic and intrinsic factors that directly or indirectly modulate Ca2+ dynamics. Furthermore, this review addresses the potential implications of understanding Ca2+ dynamics in NSCs for treating neurological disorders. Despite significant progress in this field, unraveling the elements contributing to Ca2+ intracellular dynamics in cell proliferation remains a challenging puzzle that requires further investigation.

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Section: Trpcsmentioning

confidence: 90%