Ketamine Mitigates Neurobehavioral Deficits in a Canine Model of Hypothermic Circulatory Arrest

Giuliano, Katherine; Etchill, Eric; Velez, Ana K.; Wilson, Mary Ann; Blue, Mary E.; Troncoso, Juan C.; Baumgartner, William A.; Lawton, Jennifer S.

doi:10.1053/j.semtcvs.2021.12.004

Cited by 7 publications

(5 citation statements)

References 36 publications

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“…Scores were also lower at the 72‐h evaluation, but did not reach significance (30 vs. 89, p = 0.069). Markers of neuronal injury (neurofilament‐H and neuron‐specific enolase) were also significantly lower in subjects who received ketamine treatment 28 …”

Section: Discussionmentioning

confidence: 95%

“…Markers of neuronal injury (neurofilament‐H and neuron‐specific enolase) were also significantly lower in subjects who received ketamine treatment. 28 …”

Section: Discussionmentioning

confidence: 99%

“…No significant difference was detected between ketamine and midazolam conditions. 27 A more recent preclinical study published by Giuliano et al 28 examined the effect of ketamine administered following cardiopulmonary bypass and subsequent circulatory arrest in a canine model. In this study, 1.425 mg/kg of ketamine was administered prior to the bypass procedure, and another 1.425 mg/kg following hypothermic circulatory arrest in the experimental group.…”

Section: Discussionmentioning

confidence: 99%

“…Markers of neuronal injury (neurofilament-H and neuron-specific enolase) were also significantly lower in subjects who received ketamine treatment. 28 Investigations into relative neuroprotective effects of different isomeric forms of ketamine have also been completed. Proescholdt et al investigated the effect of S(+) versus R(−) stereoisomers of ketamine on functional and structural outcomes following induction of global forebrain ischemia in a rat model.…”

Section: Discussionmentioning

confidence: 99%

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The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature

et al. 2022

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Aims The objective of this article is to summarize the state of the literature surrounding the use of ketamine as a neuroprotective agent following cardiac arrest. Methods Five electronic databases were used to search for studies related to the use of ketamine for neuroprotection following cardiac arrest. This search was performed once in May 2020, and an updated search was conducted in May 2021 and March 2022. Results All searches combined retrieved 181 results; no clinical trials were identified. As such, the authors were limited to writing a scoping review of the literature rather than a systematic review. Conclusions The current state of the literature describes the mechanism of action of ketamine as a neuroprotective agent through its action as an NMDA antagonist. There is evidence of its efficacy as a neuroprotective agent in preclinical models of cardiac arrest. Current published clinical work supports the use of ketamine ameliorating neurologic outcomes in other conditions such as epilepsy, traumatic brain injury, and depression. The current state of the literature is reflective of the notion that the use of ketamine following cardiac arrest may result in improved neurologic outcomes. Future research directions should focus on the use of ketamine as a possible clinical intervention following cardiac arrest.

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Section: Discussionmentioning

confidence: 95%

“…Markers of neuronal injury (neurofilament‐H and neuron‐specific enolase) were also significantly lower in subjects who received ketamine treatment. 28 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature

et al. 2022

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“…A recent study of patients undergoing aortic arch surgery with HCA and unilateral ACP had a 4.8% incidence of permanent neurological dysfunction [140] . A wide variety of pharmacologic agents have been studied to improve neurologic outcomes after cardiac surgery [141,142] . Among the agents that may be useful in these efforts is K ATP channel opener diazoxide [27,143] .…”

Section: The Role Of K Atp Channels In Neuroprotectionmentioning

confidence: 99%

Exploitation of K_ATP channels for cardiac surgery

Bradshaw,

Lawton

2023

Vessel Plus

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The many ways in which ATP-sensitive potassium (KATP) channels can be exploited for human benefit have expanded over recent decades. Especially since the early 2000s, research has improved our understanding of the components and mechanisms of KATP channels. They have the potential to have a prominent role in cardiac surgery. Pharmacologic and non-pharmacologic activation of KATP channels has been shown to be both cardioprotective and neuroprotective in early basic science and clinical studies. However, many questions remain unanswered and require further study, necessitating further basic science work and large human clinical trials. This review discusses the history and recent progress in the research relating to the use of KATP channels for cardiac surgery.

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Post Cardiac Arrest Care in the Cardiac Intensive Care Unit

Gonzalez,

Dahiya,

Mutirangura

et al. 2024

Curr Cardiol Rep

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Ketamine Mitigates Neurobehavioral Deficits in a Canine Model of Hypothermic Circulatory Arrest

Cited by 7 publications

References 36 publications

The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature

The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature

Exploitation of K_ATP channels for cardiac surgery

Post Cardiac Arrest Care in the Cardiac Intensive Care Unit

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Ketamine Mitigates Neurobehavioral Deficits in a Canine Model of Hypothermic Circulatory Arrest

Cited by 7 publications

References 36 publications

The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature

The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature

Exploitation of KATP channels for cardiac surgery

Post Cardiac Arrest Care in the Cardiac Intensive Care Unit

Contact Info

Product

Resources

About

Exploitation of K_ATP channels for cardiac surgery