Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions
Thi Mai Loan Nguyen,
Jean-Philippe Guilloux,
Céline Defaix
et al.
Abstract:ABSTRACT(R,S)-ketamine (ketamine) has rapid and sustained antidepressant (AD) efficacy at sub-anesthetic doses in depressed patients. A metabolite of ketamine, including (2R,6R)-hydroxynorketamine ((6)-HNKs) has been reported to exert antidepressant actions in rodent model of anxiety/depression. To further understand the specific role of ketamine’s metabolism in the AD actions of the drug, we evaluated the effects of inhibiting hepatic cytochrome P450 enzymes on AD responses. We assessed whether pre-treatment … Show more
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