Ketamine Induction In Poor-Risk Patients

NETTLES, DEXTER C.; HERRIN, THOMAS J.; MULLEN, JESSE G.

doi:10.1213/00000539-197301000-00015

Cited by 13 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ketamine has been employed in obstetrics for some years (CHODOFF & STELLA 1966, STOLP et al 1968, MOORE et al 1971. The pharmacological properties of this substance have made it useful as an anaesthetic for short-lasting operations and also as an induction agent ( CORSSEN et al 1972, LITTLE et al 1973, MEER et al 1973, NETTLES et al 1973.…”

mentioning

confidence: 99%

Ketamine and Diazepam as Anaesthesia for Forceps Delivery. A Comparative Study

Ellingson

Haram

Sagen

1977

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

In a clinically controlled trial in forceps delivery, a comparison was made between the general anaesthesia induced by ketamine and that by a combination of diazepam and N2O. Local anaesthesia was added in the diazepam group for episiotomy and suturation. The indication for operative delivery was in all cases a prolonged second stage of labour. In the katamine group, awareness was noted in four cases out of 13, even if the analgesic effect was found to be good. Four patients showed marked, short-lasting elevation of blood pressure and seven had unpleasant dreams. All thirteen mothers in the diazepam group found the anesthesia effective and the recovery pleasant. The blood pressure was stable. One mother in each group required ventilation with oxygen due to respiratory depression of short duration. Three of the children in the ketamine group and two in the diazepam group had subnormal Apgar score with slight acidosis. This was probably not attributable to the anaesthesia.

show abstract

mentioning

confidence: 99%

Ketamine and Diazepam as Anaesthesia for Forceps Delivery. A Comparative Study

Ellingson

Haram

Sagen

1977

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

“…This provided effective sedation without untoward effects on hemodynamic or respiratory function. Ketamine is often used for the induction of anesthesia in high-risk patients because of its favorable hemodynamic profile which results from the release of endogenous catecholamine stores and the inhibition of neuronal catecholamine reuptake [12]. Rare anecdotal cases of cardiovascular collapse have been reported in patients with severe myocardial dysfunction as ketamine's negative inotropic effects may predominate when endogenous catecholamine stores are depleted by chronic stress or illness [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine-Ketamine Sedation in a Patient With Dilated Cardiomyopathy

2017

View full text Add to dashboard Cite

Sedative and analgesic medications may impact physiologic function resulting in adverse effects especially in patients with co-morbid diseases. We present the successful use of a combination of dexmedetomidine and ketamine to provide sedation and analgesia in a 9-monthold patient with dilated cardiomyopathy undergoing hemodynamic cardiac catheterization with angiography. Co-morbid conditions included depressed myocardial function, hypertension, right renal artery agenesis, and narrowing of the abdominal aorta. A combination of dexmedetomidine and ketamine was used to provide procedural sedation while maintaining spontaneous ventilation. A review of previously published reports of dexmedetomidine and ketamine for procedural sedation is reviewed and the potential efficacy of this combination for procedural sedation in patients with depressed myocardial function is presented.

show abstract

“…10,37 This has led to many reported cases in anesthetic management of patients with reactive airway disease. [38][39][40][41] Beyond that, it has favorable effects clinically on systemic hemodynamics. 12,39 Unlike many of the agents discussed above, ketamine has not been shown to decrease systolic, diastolic, or mean arterial pressure in normotensive patients and, in many instances, may increase these variables.…”

Section: Discussionmentioning

confidence: 99%

The Future of Intensive Care Unit Sedation: A Report of Continuous Infusion Ketamine as an Alternative Sedative Agent

Benken

Goncharenko

2016

Journal of Pharmacy Practice

View full text Add to dashboard Cite

This report describes a patient case utilizing a nontraditional sedative, continuous infusion ketamine, as an alternative agent for intensive care unit (ICU) sedation. A 27-year-old female presented for neurosurgical management of a coup contrecoup injury, left temporal fracture, epidural hemorrhage (EDH), and temporal contusion leading to sustained mechanical ventilation. The patient experienced profound agitation during mechanical ventilation and developed adverse effects with all traditional sedatives: benzodiazepines, dexmedetomidine, opioids, and propofol. Ketamine was titrated to effect and eliminated the need for other agents. This led to successful ventilator weaning, extubation, and transition of care. Given the unique side effect profile of ketamine, it is imperative that information is disseminated on potential utilization of this agent. More information is needed regarding dosing, monitoring, and long-term effects of utilizing ketamine as a continuous ICU sedative, but given the analgesia, anesthesia, and cardiopulmonary stability, future utilization of this medication for this indication seems promising.

show abstract

Ketamine Induction In Poor-Risk Patients

Cited by 13 publications

References 0 publications

Ketamine and Diazepam as Anaesthesia for Forceps Delivery. A Comparative Study

Ketamine and Diazepam as Anaesthesia for Forceps Delivery. A Comparative Study

Dexmedetomidine-Ketamine Sedation in a Patient With Dilated Cardiomyopathy

The Future of Intensive Care Unit Sedation: A Report of Continuous Infusion Ketamine as an Alternative Sedative Agent

Contact Info

Product

Resources

About