Abstract:Highlights Ketamine induces mixed effects in animal anxiety tests Few studies investigated the individual effects of S-ketamine in anxiety/fear tests None study evaluated the effects of R-Ketamine on anxiety/fear-related behaviors Systemic ketamine does not affect panic-like behaviors in the elevated T-maze Abstract Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, presents rapid and sustained antidepressant effect in clinical and preclinical studies.Regarding ketamine effect… Show more
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