1995
DOI: 10.1097/00003246-199512000-00009
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Ketamine attenuates endotoxin-induced leukocyte adherence in rat mesenteric venules

Abstract: Pretreatment with ketamine attenuates endotoxin-induced leukocyte adherence by a shear rate-independent mechanism, suggesting reduced expression of adhesion molecules. These results indicate that ketamine exerts an anti-inflammatory effect, which might be beneficial in septic patients.

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Cited by 50 publications
(17 citation statements)
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“…Ketamine inhibits the expression of adhesion molecules on infl ammatory cells in both in vivo and in vitro studies. 43,44 However, an in vitro study on endothelial cells failed to observe any effects on ICAM-1 expression, 27 consistent with the current results. The effects on sP-selectin levels were correlated well with injury grade, and could explain the lower leukocyte infi ltration observed in the ketamine-pretreated rats subjected to intestinal I/R.…”
Section: Discussionsupporting
confidence: 90%
“…Ketamine inhibits the expression of adhesion molecules on infl ammatory cells in both in vivo and in vitro studies. 43,44 However, an in vitro study on endothelial cells failed to observe any effects on ICAM-1 expression, 27 consistent with the current results. The effects on sP-selectin levels were correlated well with injury grade, and could explain the lower leukocyte infi ltration observed in the ketamine-pretreated rats subjected to intestinal I/R.…”
Section: Discussionsupporting
confidence: 90%
“…However, the subsequent neutrophilic leukocytosis was earlier (5 versus 8 hours) and significantly greater in the KET group (leukocytosis at 8 hours and neutrophilia at 8 and 24 hours) compared with the SAL group. The effect of subanesthetic ketamine on equine leukocyte function, specifically neutrophils, has not been studied in the horse but has been explored in humans where ketamine demonstrated anti‐inflammatory effects via inhibition of neutrophil adhesion molecule expression in vitro 26,33 . Interestingly in this study, the anticipated leukocytosis and neutrophilia that commonly occur in healthy horses after LPS administration were significantly amplified in the KET group, which may be a consequence of attenuated adhesion molecule expression.…”
Section: Discussionmentioning
confidence: 69%
“…Additionally, ketamine significantly limits the diapedesis of the neutrophils to the site of inflammation [48][49][50]. The underlying mechanism appears to be a reduction in adhesion molecules expressed on the surface of the immune cell [51] and not an interaction with the inflammatory endothelial function [48].…”
Section: Ketamine As a "Regulator" Of The Inflammatory Reaction: Precmentioning
confidence: 99%