Ketamine as an alternative to midazolam co-induction to propofol: a comparative study

Yadav, Rupesh Kumar; Bajracharya, Gautam Ratna; Pokharel, Jeju Nath

doi:10.3126/jsan.v2i2.13532

Cited by 2 publications

(2 citation statements)

References 6 publications

(3 reference statements)

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“…The study showed statistically significant difference between the two groups. 9 Ketamine group had least change in heart rate from baseline compared to midazolam group similarly, Srivastava et al 10 compared hemodynamic changes during induction using ketamine and midazolam as a co-induction agent to propofol among sixty-eight patients of ASA I and II undergoing elective surgery. They concluded that ketamine group had least change in heart rate from baseline which further supports our study.…”

Section: Discussionmentioning

confidence: 99%

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Anesthetic Properties of Propofol and Ketofol (Ketamine With Propofol): A Comparative Study

Yadav¹,

Thapa²,

Sah³

et al. 2022

JCMC

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Background: Surgical procedures require a safe anesthesia and safe anesthetic agents for this purpose use of small dose of sedative agent or any other anesthetic agent in order to reduce the dose requirement as well as adverse effects of the main inducing agent. Therefore, this study was carried out using ketamine with propofol (KETOFOL) to compare the hemodynamic stability (Heart rate and Mean arterial pressure) and induction doses. Methods: Fifty patients of age 18 to 60 years of ASA II and I scheduled for elective surgery to be performed under general anaesthesia were randomly selected and divided into two groups. Patient in Group-P received 50 mg propofol and Group-K received 50 mg (25mg ketamine with 25 mg propofol) intravenously bolus slowly and then 10 mg in every 10 seconds until the loss of eyelash reflex and verbal response. The hemodynamic response was noted at different given time. Chi square test and student’s t test were used for analysis. Results: The study showed that the hemodynamic (heart rate and mean arterial pressure) was maintained and decrease in dose requirement for propofol for induction in (ketamine with propofol Ketofol group whereas there was significant decrease in hemodynamic (heart rate and mean arterial pressure) in Propofol group. Conclusions: Our study concluded that fluctuations in heart rate and mean arterial pressure from baseline were more in propofol group compared to ketofol (ketamine with propofol) group. Therefore, Ketofol achieved better hemodynamic stability over propofol alone and also induction dose of propofol was reduced.

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Section: Discussionmentioning

confidence: 99%

“…Similar findings like our study was seen in Yadav et al, Srivastava et al and Kalita A and Ahmed ALM. [9][10][11] They concluded that ketamine provides better hemodynamic stability as a co-induction agent.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic Properties of Propofol and Ketofol (Ketamine With Propofol): A Comparative Study

Yadav¹,

Thapa²,

Sah³

et al. 2022

JCMC

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A Comparative Study of Small Dose of Ketamine and Midazolam as Co-Induction Agents to Propofol in Patients Undergoing Elective Surgeries under General Anaesthesia

Ubeja¹,

Ravishankar²

2020

jemds

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BACKGROUND Intravenous anaesthesia is an integral part of modern anaesthesia. But till date there is no single intravenous agent which fulfils all the characteristics of an ideal anaesthetic agent. The technique of co-induction is to administer a subanaesthetic dose of another inducing or sedative agent, so as to reduce the dose of primary agent. Propofol in the most frequently used IV anaesthetic agent used today, providing faster onset of action, antiemesis, rapid recovery with attenuation of pharyngeal, laryngeal and tracheal reflexes. The major disadvantages of propofol induction are impaired cardiovascular and respiratory function, which may put the patient at a higher risk of bradycardia, hypotension and apnoea. METHODS 150 patients of either sex in the age group of 18 to 65 years, undergoing elective surgeries were randomly selected and informed consents were taken. The study population was divided into three groups with 50 patients in each group. Group KP- 0.4 mg/Kg ketamine; Group MP- 0.03 mg/Kg midazolam and Group C- 10 mL NS. RESULTS Requirement of induction dose was reduced in both the groups and the induction dose was the least in group KP. Changes in haemodynamic parameters ere greater in group c and group MP as compared to group KP. CONCLUSIONS Co-induction with ketamine provides better hemodynamic stability and lesser induction dose of propofol as compared to midazolam. Therefore, ketamine is preferred as a co-induction agent to propofol. KEYWORDS Propofol, Ketamine, Midazolam

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Ketamine as an alternative to midazolam co-induction to propofol: a comparative study

Cited by 2 publications

References 6 publications

Anesthetic Properties of Propofol and Ketofol (Ketamine With Propofol): A Comparative Study

Anesthetic Properties of Propofol and Ketofol (Ketamine With Propofol): A Comparative Study

A Comparative Study of Small Dose of Ketamine and Midazolam as Co-Induction Agents to Propofol in Patients Undergoing Elective Surgeries under General Anaesthesia

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