Kernicterus and Prematurity

Aidin, R.; Corner, Beryl D.; Tovey, Geoffrey H.

doi:10.1016/s0140-6736(50)90951-2

Cited by 73 publications

(15 citation statements)

References 9 publications

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“…The condition is generally regarded as an innocuous one; as is implied by the customary description-" physiological jaundice." However, a more serious view is suggested by recent reports (Aidin et al, 1950;Claireaux et al, 1953), which show that prematurity and jaundice may be followed by pigmentation of the brain and death of the infant. This association had led us to re-examine the relation between birth weight and the incidence, degree, and duration of the increased bile-pigment content of the plasma of newborn babies.…”

Section: Discussionmentioning

confidence: 99%

Increased Plasma Bilirubin in Newborn Infants in Relation to Birth Weight

Billing¹,

Cole²,

Lathe³

1954

BMJ

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Section: Discussionmentioning

confidence: 99%

Increased Plasma Bilirubin in Newborn Infants in Relation to Birth Weight

Billing¹,

Cole²,

Lathe³

1954

BMJ

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“…Most term neonates, and virtually all preterm infants, will experience some degree of jaundice. Bilirubin is a poten tially toxic byproduct of heme metabolism, and the neurotoxic effects of severe hyperbili rubinemia are well known [6,7]. The treat ment of jaundice has been more aggressive in premature infants [8] because they are thought to be at greater risk of kernicterus.…”

Section: Introductionmentioning

confidence: 99%

Influence of Bilirubin on the Antioxidant Capacity of Plasma in Newborn Infants

Bélanger

Lavoie

Chessex³

1997

Neonatology

118

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In vitro, bilirubin is a strong antioxidant, but in vivo its capacity to act as a scavenger of toxic oxygen radicals remains poorly documented. The aim of this study was to evaluate if bilirubin had antioxidant properties in jaundiced infants. The antioxidant capacity of neonatal plasma was measured in Trolox equivalents (TEAC, mmol/l) and correlated in vitro with plasma bilirubin concentrations (r² = 0.99). Plasma TEAC was compared before and after exchange transfusions for neonatal hyperbilirubinemia (250–435 μmol/l). The antioxidant properties of the paired blood samples before and after exchange transfusions (TEAC: 1.67 ± 0.12 vs. 1.37 ± 0.09 mmol/l, n = 11) varied in proportion to the serum bilirubin levels. The changes in other antioxidants were not large enough to account for the magnitude of change in antioxidant capacity. Therefore, in vivo, the plasma antioxidant capacity of jaundiced newborn infants is related to the level of bilirubin.

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“…4,5 At first, kernicterus in preterm infants was thought to occur only in association with marked hyperbilirubinemia. However, during the mid-1960s through the early 1970s, kernicterus was frequently observed at serum bilirubin levels previously considered safe.…”

mentioning

confidence: 99%