Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome

Nathani, Nazim; Perkins, Gavin D.; Tunnicliffe, William; Murphy, Nick; Manji, Mav; Thickett, David

doi:10.1186/cc6785

Cited by 52 publications

(41 citation statements)

References 18 publications

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“…Another ATII cell product that has been investigated as a marker of ARDS is the KL-6 protein, a secreted glycoprotein normally found in the alveolar space. Multiple studies have shown increased levels of KL-6 in both BALF and serum samples from ARDS patients relative to 'at-risk' and healthy controls [10,17,26,27]. The presence of KL-6 in the serum is presumed to indicate breakdown of the alveo-capillary barrier.…”

Section: The Epithelial Markersmentioning

confidence: 99%

Biomarkers in acute respiratory distress syndrome

Binnie

Tsang

Santos

2014

Current Opinion in Critical Care

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Section: The Epithelial Markersmentioning

confidence: 99%

Biomarkers in acute respiratory distress syndrome

Binnie

Tsang

Santos

2014

Current Opinion in Critical Care

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“…In case of respiratory tract infections local disease markers such as proteins present in bronchoalveolar lavage fluid (BALF) are likely to be most meaningful [13,35,53]. In order to identify potential markers, proteome analysis of BALF performed with two dimensional gel electrophoresis (2-D PAGE) followed by mass spectrometry has become the method of choice [37,52].…”

Section: Introductionmentioning

confidence: 99%

Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance toActinobacillus pleuropneumoniaeinfection

D¹,

Buettner²,

Naim³

et al. 2009

Vet. Res.

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-Biomarkers facilitating both pathogen-independent diagnosis of respiratory health and breeding selection of pigs with increased resistance to respiratory tract infections would be of considerable interest to the pig industry. Following this concept we performed a comparative glycoproteome analysis of bronchoalveolar lavage fluid (BALF) from healthy pigs and pigs 4 days (acute) and 20 days (chronic) after an experimental infection with Actinobacillus pleuropneumoniae. In order to identify possible differences in BALF glycoprotein patterns we investigated pigs of three different breeding lines (German Landrace, Piétrain, Hampshire). In total, 12 glycosylated proteins (alpha-1-acid glycoprotein, fetuin A, properdin, haptoglobin precursor, haptoglobin, hemoglobin, hyaluronidase, inter-alpha-trypsin inhibitor family heavy chain-related protein, alpha-1-antichymotrypsin 3, pulmonary surfactant-associated protein D (SP-D), transferrin, and alpha-1B-glycoprotein) were identified as being differentially expressed depending on the health status of the animal. Fetuin A levels were consistently low in chronically infected pigs thereby being a potential marker for chronic infection. Hyaluronidase levels were consistently high in all pigs after experimental infection independent on isolation of the pathogen thereby being a potential marker for previous pathogen contact and latent infection. High levels of fetuin A as well as low levels of haptoglobin and pulmonary SP-D correlated with the absence of lung lesions in pigs of the Hampshire breeding line, implying a potential application as selection markers for breeding programmes.porcine respiratory disease / glycoprotein analysis / bronchoalveolar lavage fluid / biomarker

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“…Therefore, KL-6 in alveolar fluid easily moves to the serum. These mechanisms result in elevated serum levels of KL-6 in active interstitial lung disease [9][10][11]. Therefore, KL-6 is a useful biological marker to evaluate the activity of interstitial lung disease [12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%