Keratouveitis as a First Presentation of Relapsing Polychondritis

Sallam, Ahmed B.; Islam, Tahmina; Parmar, Dipak N.

doi:10.1155/2010/176514

Cited by 9 publications

(16 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another series found that 8.2% of the patients with scleritis-associated uveitis had RP (14). Typically, nongranulomatous anterior uveitis is seen (15), often in conjunction with scleritis. Cyclitic membranes have been reported (16); however, hypopyon uveitis without scleritis is very exceptional (17).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Anterior Uveitis with Hypopyon Revealing Relapsing Polychondritis

et al. 2012

View full text Add to dashboard Cite

Relapsing polychondritis (RP) is a rare disease involving cartilaginous structures, predominantly the ears, nose and laryngotracheobronchial tree. The eyes, cardiovascular system, peripheral joints, skin, and central nervous system may also be affected. Involvement of all ocular structures has been described. Nongranulomatous uveitis is a common feature; however hypopyon is uncommon. We herein present the case of a 42-year-old man who had been diagnosed with bronchial asthma for a long period; and who presented with recurrent hypopyon uveitis as a revealing manifestation of relapsing polychondritis. We emphasize that RP should therefore be considered in the differential diagnosis of sterile hypopyon uveitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Recurrent Anterior Uveitis with Hypopyon Revealing Relapsing Polychondritis

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Relapsing polychondritis mainly affects cartilaginous tissues and collagen-rich tissues. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 Eyeballs are collagen-rich organs that are unavoidable sites of inflammation in patients with relapsing polychondritis, with the affected areas including the conjunctiva, sclera, cornea, uvea, retina, and optic nerve. Therefore, conjunctivitis, episcleritis or scleritis, keratitis, uveitis, and retinopathy are very common ocular manifestations in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…Relapsing polychondritis is an unusual multiorgan autoimmune disease characterized by recurrent inflammation and progressive destruction of cartilaginous structures and collagen-rich tissues, including the eyes, ears, nose, skin, renal, musculoskeletal, heart, and respiratory systems. 1 , 2 , 3 , 4 , 5 , 6 , 7 Ocular manifestations, including proptosis, eyelid edema, conjunctivitis, episcleritis, keratitis, uveitis, secondary open glaucoma, and retinopathy often occur in more than half of patients with relapsing polychondritis. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 We experienced the case of a patient with relapsing polychondritis who presented with ocular complications, including conjunctivitis, episcleritis, keratouveitis, secondary angle closure glaucoma, and complicated cataract.…”

Section: Introductionmentioning

confidence: 99%

Surgical interventions for late ocular complications of relapsing polychondritis

Liu

et al. 2017

American Journal of Ophthalmology Case Reports

View full text Add to dashboard Cite

PurposeTo report a case of surgical interventions for a patient with relapsing polychondritis who presented with late ocular complications.ObservationsA 44-year-old male was diagnosed to have relapsing polychondritis on the basis of recurrent acute auricular chondritis, deformity of the ear, saddle nose deformity and painful nasal chondritis, acute ocular inflammation with conjunctivitis, episcleritis and keratouveitis, laryngotracheal chondritis, erythema nodosum in the skin, a history of polyarthritis, and abnormal blood examination findings. The acute ocular and auricular inflammation was resolved with oral corticosteroid treatment. Intraocular pressure (IOP) of the left eye was 60 mmHg as measured by Goldmann applanation tonometer. Gonioscopic observation revealed the presence of peripheral anterior synechiae and plateau iris configuration. Express drainage screw implantation was applied to the left eye, because topical and systemic medicines failed to decrease the IOP. After 12 months, complicated cataract aggravated in the right eye, and phacoemulsification operation was performed with corticosteroids administered during the perioperative period. His corrected visual acuity was 20/20 for the right eye, and the IOP remained below 21 mmHg for the left eye. The patient has been healthy, without any recurrence, for 36 months.Conclusions and importanceThe present case of relapsing polychondritis is the first to be reported wherein late ocular complications were alleviated by surgical interventions. Routine use of corticosteroids is necessary for successful anti-glaucoma and phacoemulsification operations.

show abstract

“…RP most commonly presents as auricular chondritis and polyarthritis, which occur in over 80% of patients, 31 but RP can affect almost every organ system ( Table 2). Constitutional symptoms include fever, fatigue, weight loss, night sweats, and enlarged inguinal lymph nodes.…”

Section: Systemic Diseasementioning

confidence: 99%

“…3,28 Corneal infiltrates in RP, sometimes associated with a hypopyon, can mimic infectious keratitis. 10,31 Uvea According to Letko, uveitis occurs in about 25% of RP patients and is usually anterior uveitis or sclerouveitis. 28 Hypopyon uveitis may occur as a presenting feature of RP.…”

Section: Corneamentioning

confidence: 99%

Relapsing Polychondritis: Systemic and Ocular Manifestations, Differential Diagnosis, Management, and Prognosis

Yoo¹,

Chodosh²,

Dana³

2011

Seminars in Ophthalmology

View full text Add to dashboard Cite

Relapsing polychondritis (RP) is a rare systemic autoimmune disease characterized by episodic inflammation of cartilaginous tissues throughout the body. It is distinguished by recurrent bouts of inflammation, which lead to the permanent destruction of the involved structures. It can be a life-threatening, debilitating, and frightening disease and is often difficult to diagnose in its early stages. Ocular manifestations have been reported to occur in up to 65% of cases and include proptosis, eyelid edema, extraocular muscles palsy, episcleritis, scleritis, conjunctivitis, corneal infiltrate, peripheral ulcerative keratitis, corneal thinning or perforation, iridocyclitis, cataract, retinopathy, exudative retinal detachment, and optic neuritis. Corticosteroids remain the mainstay of treatment for RP; however, other treatment modalities include nonsteroidal anti-inflammatory drugs, colchicine, dapsone, and immunomodulatory drugs. This article reviews the literature and summarizes the epidemiology, pathogenesis, clinical features, treatment, and prognosis of the systemic and ocular manifestations of RP.

show abstract

Keratouveitis as a First Presentation of Relapsing Polychondritis

Cited by 9 publications

References 3 publications

Recurrent Anterior Uveitis with Hypopyon Revealing Relapsing Polychondritis

Recurrent Anterior Uveitis with Hypopyon Revealing Relapsing Polychondritis

Surgical interventions for late ocular complications of relapsing polychondritis

Relapsing Polychondritis: Systemic and Ocular Manifestations, Differential Diagnosis, Management, and Prognosis

Contact Info

Product

Resources

About