Keratotic lupus erythematosus: Treatment with isotretinoin

Rubenstein, Daniel Jay; Huntley, Arthur C.

doi:10.1016/s0190-9622(86)70111-4

Cited by 47 publications

(20 citation statements)

References 7 publications

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“…These KA-like proliferations respond to retinoids and steroids, offering supportive evidence that they are HLE-related rather than neoplastic proliferations. 3,4 In some patients, hyperkeratotic lesions may evolve into cribriform scars. Cutaneous manifestations may be chronic and progressive, but systemic LE is not present in most cases.…”

Section: Pathologic Findingsmentioning

confidence: 99%

Cutaneous Hypertrophic Lupus Erythematosus: A Challenging Histopathologic Diagnosis in the Absence of Clinical Information

Arps

Patel

2013

Archives of Pathology &Amp; Laboratory Medicine

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Hypertrophic lupus erythematosus (HLE) is rare variant of chronic cutaneous lupus characterized histologically by irregular epidermal hyperplasia associated with features of classic chronic cutaneous lupus, including interface changes. Lesions frequently demonstrate reactive squamous atypia of the basal layer and may show histopathologic overlap with other more common cutaneous atypical squamoproliferative lesions. Typical histologic features of cutaneous lupus, such as follicular plugging, angiocentric lymphocytic inflammation, and dermal mucin, are very helpful clues to the diagnosis of hypertrophic lupus erythematosus. Recently, immunohistochemistry for CD123 used to detect increased plasmacytoid dendrocytes in hypertrophic lupus erythematosus has proven to be diagnostically useful. A high index of suspicion for hypertrophic lupus erythematosus is essential to avoid overdiagnosis of squamous neoplasia, particularly in limited cutaneous biopsies in the absence of adequate clinical information.

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Section: Pathologic Findingsmentioning

confidence: 99%

Cutaneous Hypertrophic Lupus Erythematosus: A Challenging Histopathologic Diagnosis in the Absence of Clinical Information

Arps

Patel

2013

Archives of Pathology &Amp; Laboratory Medicine

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“…[6–9] Acitretin, isotretinoin and combination therapy of isotretinoin with hydroxychloroquine have been used to treat resistant hypertrophic lupus erythematosus, but the response is usually short-lived and maintenance therapy is required. In our case, combination of isotretinoin with hydroxychloroquine proved highly effective and the hyperkeratotic plaques disappeared promptly within the first three months of treatment but the patient relapsed after stopping the therapy; so he was started on isotretinoin again.…”

Section: Discussionmentioning

confidence: 99%

Extensive hypertrophic lupus erythematosus: Atypical presentation

et al. 2012

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Lupus erythematosus (LE) is a disease with a wide spectrum of cutaneous and systemic manifestations. Clinical features of patients with LE show a great variation, and for this reason it is difficult to develop a unifying concept of this disease. Our objective is to present a case of hypertrophic LE with atypical morphology and extensive involvement, who responded favorably to isotretinoin. Diagnosis of hypertrophic lupus erythematosus (HLE) was confirmed by characteristic histopathological findings. Combination therapy with isotretinoin and hydroxychloroquine resulted in flattening and repression of previously refractory skin lesions. Sometimes, HLE lesions may present a diagnostic and therapeutic dilemma. In long standing lesions, squamous cell carcinoma may arise. Therefore, HLE requires adequate therapy with clinical and histopathological follow up.

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“…Systemic retinoids can be used alone or in combination with antimalarials. Acitretin (11, 12), isotretinoin (6) or a combination therapy of isotretinoin with hydroxychloroquin (4) have been reported to be successful in treating resistant hypertrophic LE.…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic Lupus Erythematosus Treated Successfully with Acitretin as Monotherapy

Al-Mutairi

Rijhwani

Nour-Eldin

2005

The Journal of Dermatology

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Hypertrophic lupus erythematosus (HLE) is a distinct and rare subset of chronic cutaneous lupus erythematosus characterized by verrucous lesions which are chronic in course and resistant to treatment (1). We describe the successful use of acitretin in a patient with HLE who had multiple hyperkeratotic verrucous plaques over the dorsa of his hands, feet, and legs and who failed to respond to local steroids and antimalarials.

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Keratotic lupus erythematosus: Treatment with isotretinoin

Cited by 47 publications

References 7 publications

Cutaneous Hypertrophic Lupus Erythematosus: A Challenging Histopathologic Diagnosis in the Absence of Clinical Information

Cutaneous Hypertrophic Lupus Erythematosus: A Challenging Histopathologic Diagnosis in the Absence of Clinical Information

Extensive hypertrophic lupus erythematosus: Atypical presentation

Hypertrophic Lupus Erythematosus Treated Successfully with Acitretin as Monotherapy

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