Keratosis Punctata of the Palmar Creases

Abstract

Figure 1 Left hand with scattered pits along palmar creases characteristic of KPPC.

Palmar pits

“…KPPC is a benign hyperkeratotic dermatosis. 1 Its aetiology is unknown, but as lesions occur at the sites of acrosyringia, it has been theorized that it may result from sweat gland pathology. 2 It has an estimated prevalence of 1.5-3% among African males, may be associated with friction, and is thought to be autosomal dominant.…”

“…2 It has an estimated prevalence of 1.5-3% among African males, may be associated with friction, and is thought to be autosomal dominant. 1,3 Typically, lesions develop during puberty, forming hyperkeratotic plugs which eventually break off, resulting in residual chronic pits. 1 Histological findings include hyperkeratotic plugs depressing the epidermis.…”

“…1,3 Typically, lesions develop during puberty, forming hyperkeratotic plugs which eventually break off, resulting in residual chronic pits. 1 Histological findings include hyperkeratotic plugs depressing the epidermis. 1 Feet are rarely affected.…”

“…1 Histological findings include hyperkeratotic plugs depressing the epidermis. 1 Feet are rarely affected. It is distinct from other palmar pit conditions, being located exclusively in the palmar creases, differentiating it from verrucae vulgaris, spiny keratoderma, palmoplantar keratoderma, arsenical keratosis and syphilitic keratosis.…”

Knuckle lesions in inherited and acquired disorders

“…It should be differentiated from keratosis punctata palmoplantaris, which is characterized by multiple palmoplantar pits and being associated with atopy, nail dystrophy and colorectal malignancy. [ 12 13 ]…”