Keratosis Blennorrhagica Successfully Treated With Corticotropin (Acth)

Value if Treatment in Reiter'S Disease

“…The results of streptomycin, aureomycin, and chloramphenicol therapy in these cases are very similar to those obtained by us and need not be discussed further, except to note that both streptomycin (Levy, 1951) and aureomycin (Ford, 1953) failed to arrest the syndrome when urethritis was the sole manifestation. Terramycin (12 g.) had no effect in the case reported by Myerson and Katzenstein (1952). Willcox and Findlay (1952a, b) described the effects of terramycin in five cases; in one case recovery followed 12*5 g. terramycin, while 6, 12-5, and 19-5 g. respectively had little or no effect in three cases, and arthritis developed in the remaining case after 6 g. terramycin had been given for urethritis.…”

“…In one case, however, ACTH (750 mg. in 5 days) and cortisone (1,000 mg. in 5 days) had no beneficial effect when given early in the illness, but did have a suppressive effect after the illness had been present for 80 days. The illness had been present for 3 months in the case reported by Myerson and Katzenstein (1952) when hormone therapy was instituted. A course of 1,800 mg. cortisone in 11 days was followed at monthly intervals by two courses of ACTH (1,360 mg. in 17 days).…”

“…Successful results have also been claimed for penicillin (Freireich, Schwartz, and Steinbrocker, 1947), streptomycin (Thompson, White, and Hailey, 1949), antihistamines alone and combined with streptomycin (Levy, 1951), the widespectrum antibiotics (Korb and Brown, 1950;Findlay and Willcox, 1951 ;Harkness, 1953), gold salts (Willcox, Findlay, and Henderson-Begg, 1947), and cortisone and ACTH (Ogryzlo and Graham, 1950;Myerson and Katzenstein, 1952).…”