Keratoprosthesis with retrocorneal fixation: preliminary results in dogs with corneal blindness

Isard, Pierre‐François; Dulaurent, Thomas; Régnier, A.

doi:10.1111/j.1463-5224.2010.00800.x

Cited by 7 publications

(7 citation statements)

References 27 publications

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“…While PK has been described in dogs, corneal, or endothelial keratoplasty transplantation techniques have not yet been developed for widespread use in canine PCED cases . Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye …”

Section: Discussionmentioning

confidence: 99%

“…[34][35][36] Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye. 37,38 Assessment of the population of PCED dogs from a veterinary ophthalmic clinic provided disease signalment information beyond previous publications. Some studies assessing a relatively small study population have shown a sex predilection in female dogs; 5,6 however, this finding has not been consistent across all studies.…”

Section: Discussionmentioning

confidence: 99%

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Superficial keratectomy as a treatment for non‐healing corneal ulceration associated with primary corneal endothelial degeneration

Bayley

Read

Gates

2018

Veterinary Ophthalmology

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Objective To analyze a study population of dogs with primary corneal endothelial degeneration (PCED) for information on the patterns of disease and to report the efficacy of superficial keratectomy (SK) for resolution of non‐healing corneal ulcers associated with PCED. Animals studied Primary corneal endothelial degeneration was diagnosed in 238 dogs between 1998 and 2017. Corneal ulceration associated with PCED was present in 89 dogs (109 eyes), of which 47 eyes were treated with SK. Procedures A retrospective assessment of medical records was performed to determine the signalment patterns of PCED, and the success rate of the SK procedure for resolving PCED‐associated corneal ulceration. Descriptive statistics were reported on the signalment of PCED cases, with odd ratios and confidence intervals calculated to detect breed predispositions. Results Primary corneal endothelial degeneration was diagnosed in 238 dogs, 40.8% were female and 59.2% were male, with a mean age at diagnosis of 11.4 years. Dachshunds, Dalmatians, English Springer Spaniels, Welsh Springer Spaniels, Chihuahuas, Cocker Spaniels, and Golden Retrievers were significantly over‐represented. All PCED‐affected Dalmatians developed associated corneal ulceration. Follow‐up information was available for 41/47 eyes treated with SK. At the first reassessment, 87.8% were healed which increased to 97.6% with subsequent monitoring. Four eyes (9.8%) had late corneal ulcer occurrence following SK, at a median time following SK of 182 weeks post‐surgery. Conclusions Superficial keratectomy was an effective option for resolving painful non‐healing corneal ulcers associated with PCED. Dalmatians may be at increased risk of developing PCED‐associated corneal ulceration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Superficial keratectomy as a treatment for non‐healing corneal ulceration associated with primary corneal endothelial degeneration

Bayley

Read

Gates

2018

Veterinary Ophthalmology

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Section: Discussionmentioning

confidence: 99%

“…Corneal scarring and conjunctivalization following an alkaline injury can lead to corneal blindness in dogs, and an attempt has been made to place a keratoprosthesis in an affected cornea . Initially, vision was restored in that case, but was then lost again due to postoperative coverage of the prosthesis' optic by granulation tissue . It should be considered that corneal tissue can take several months to clear, as shown in case 3, potentially resulting in clearing of an initially fully vascularized cornea over several months with a good visual outcome.…”

Section: Discussionmentioning

confidence: 99%

Ocular alkaline injury in four dogs – presentation, treatment, and follow‐up – a case series

Busse

Hartley

Kafarnik

et al. 2014

Veterinary Ophthalmology

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The damage to the ocular structures described here mainly affects the ocular surface. One patient presumably suffered an injury to the ciliary body epithelium resulting in a phthisical globe. Chronic corneal edema, conjunctivalization, and scarring can result in permanent visual impairment. Healing of the ocular surface can take weeks and is associated with a dramatic vascular response. However, a severely vascularized cornea has the potential to clear and allow a good visual outcome long term. Ongoing discomfort was only seen in one case with persistent corneal edema and a secondary bullous keratopathy.

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“…In veterinary medicine, the loss of corneal transparency may occur in response to various diseases such as corneal pigmentation, chronic superficial keratitis, severe stromal edema or fibrosis, keratoconjunctivitis sicca, and ulceration. Long-term medical or surgical therapies can be applied for non-treated cases despite initial treatment [7]. In such cases, the only alternative treatment has been the surgical application of an artificial cornea (keratoprosthesis) to restore vision [9].…”

mentioning

confidence: 99%

Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits

Hwang

Kim

2016

Lab Anim Res

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Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMA-PMMA [poly (2-hydroxyl methacrylate)-poly (methyl methacrylate)] keratoprostheses in rabbits following penetrating keratoplasty. Sixteen male New Zealand White rabbits aged 16 weeks were divided into three groups. Group I and group II contained six rabbits each, while the control group had four rabbits. Experimental surgery was conducted under general anesthesia. The cornea was penetrated using an 8 mm diameter biopsy punch. In group I (core 5 mm & skirt 3 mm) and group II (core 6 mm & skirt 2 mm), the keratoprosthesis was placed into the recipient full thickness bed and sutured into position with double-layer continuous. In the control group, corneal transplantation using normal allogenic corneal tissue was performed with the same suture method. After four and eight weeks, keratoprosthesis devices were evaluated by histopathological analysis of gross lesions. Post-operative complications were observed, such as extrusion and infection in experimental groups. Most corneas were maintained in the defect site by double-layer continuous suture materials for 4 weeks and kept good light transmission. However, most artificial cornea were extruded before 8 weeks. Overall, combined PHEMA and PMMA appears to have sufficient advantages for production of artificial corneas because of its optical transparency, flexibility and other mechanical features. However, the stability and biocompatibility were not sufficient to enable application in humans and animals at the present time using penetrating keratoplasty. Further studies are essential to improve the stability and biocompatibility with or without other types of keratoplasty.

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Keratoprosthesis with retrocorneal fixation: preliminary results in dogs with corneal blindness

Cited by 7 publications

References 27 publications

Superficial keratectomy as a treatment for non‐healing corneal ulceration associated with primary corneal endothelial degeneration

Superficial keratectomy as a treatment for non‐healing corneal ulceration associated with primary corneal endothelial degeneration

Ocular alkaline injury in four dogs – presentation, treatment, and follow‐up – a case series

Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits

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