Keratomycosis caused by an Alternaria species

Subconjunctival Injection of Fluconazole in the Treatment of FungalAlternariaKeratitis

“…11 Although several in vitro antifungal sensitivity analyses showed fluconazole to be less effective to filamentous fungi, 12 clinical response to topical fluconazole was reported anecdotally. 4,8 Good response to systemic fluconazole in systemic Alternaria infections was also reported. 13 In our opinion, this agent may merit further investigation for its antifungal effects.…”

“…5 Although Alternaria keratitis has been reported in several articles from other parts of the world, [4][5][6][7] it was less commonly reported in East Asia. 8,9 To our knowledge, these are the rare reports showing human keratitis infected by Alternaria species refractory to the conventional antifungal medical treatment treated successfully by subconjunctival fluconazole injection. A review of the literature indicates that several different antifungal agents have been used for the therapy of Alternaria keratitis, but no clear standard therapeutic approach has been established.…”