Keratoglobus

Cameron, James Alexander

doi:10.1097/00003226-199303000-00006

Cited by 58 publications

(50 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This led them to hypothesise that the natural history of pellucid marginal degeneration may be in the development of keratoglobus by circumferential extension of the peripheral gutter. Similarly, Cameron 14 described a case report documenting kerotoconus progressing into a keratoglobus-like picture. However, a constant association and progression between these ectatic disorders has not been described to validate these hypotheses.…”

Section: Aetiological Factorsmentioning

confidence: 96%

“…11,12 Keratoglobus has also been described in cases of Leber's congenital amaurosis. 13 The acquired forms of keratoglobus have been described in association with vernal keratoconjunctivitis, chronic marginal blepharitis, idiopathic orbital inflammation, 14 and dysthyroid eye disease. 15 In the case of vernal keratoconjunctivitis and chronic marginal blepharitis, the corneal ectasia may be related to frequent eye-rubbing.…”

Section: Aetiological Factorsmentioning

confidence: 99%

“…15 In the case of vernal keratoconjunctivitis and chronic marginal blepharitis, the corneal ectasia may be related to frequent eye-rubbing. 14,16 This has been thought by some authors to be a factor in the development of keratoconus, although the exact mechanism of such an association has not been proven. 17 Overlaps in aetiological factors between keratoconus, pellucid marginal degeneration, and keratoglobus, such as their manifestations in connective tissue disorders and various acquired forms has further fuelled the speculation about their being different spectrums of the same disease.…”

Section: Aetiological Factorsmentioning

confidence: 99%

“…17 Overlaps in aetiological factors between keratoconus, pellucid marginal degeneration, and keratoglobus, such as their manifestations in connective tissue disorders and various acquired forms has further fuelled the speculation about their being different spectrums of the same disease. Also, there are reports of keratoconus and keratoglobus, 3,14,18 as well as pellucid marginal corneal degeneration (PMCD) and keratoglobus 19,20 being clinically documented in the same patient over time. Poliquen et al 4 classified keratoglobus into two types, one being congenital and the other acquired.…”

Section: Aetiological Factorsmentioning

confidence: 99%

“…However, a constant association and progression between these ectatic disorders has not been described to validate these hypotheses. In the reports of keratoglobus associated with thyroid ophthalmopathy 15 and orbital inflammatory disease, 14 the authors hypothesise ischaemia of the 6,60,61 Mental retardation, postnatal growth deficiency, microcephaly, broad thumbs and big toes, congenital heart defects, joint hypermobility, obesity…”

Section: Aetiological Factorsmentioning

confidence: 99%

See 4 more Smart Citations

Keratoglobus

Wallang

Das²

2013

Eye

View full text Add to dashboard Cite

Keratoglobus is a rare noninflammatory corneal thinning disorder characterised by generalised thinning and globular protrusion of the cornea. It was first described as a separate clinical entity by Verrey in 1947. Both congenital and acquired forms have been shown to occur, and may be associated with various other ocular and systemic syndromes including the connective tissue disorders. Similarities have been found with other noninflammatory thinning disorders like keratoconus that has given rise to hypotheses about the aetiopathogenesis. However, the exact genetics and pathogenesis are still unclear. Clinical presentation is characterised by progressive diminution resulting from irregular corneal topography with increased corneal fragility due to extreme thinning. Conservative and surgical management for visual rehabilitation and improved tectonic stability have been described, but remains challenging. In the absence of a definitive standard procedure for management of this disorder, various surgical procedures have been attempted in order to overcome the difficulties. This article reviews the aetiological factors, differential diagnosis, histopathology, and management options of keratoglobus.

show abstract

Section: Aetiological Factorsmentioning

confidence: 96%