Kératoglobe : revue de la littérature

Baillif, S.; Garweg, Justus G.; Grange, Jean‐Daniel; Burillon, C.; Kodjikian, Laurent

doi:10.1016/s0181-5512(05)81154-4

Cited by 15 publications

(6 citation statements)

References 24 publications

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“…17 Overlaps in aetiological factors between keratoconus, pellucid marginal degeneration, and keratoglobus, such as their manifestations in connective tissue disorders and various acquired forms has further fuelled the speculation about their being different spectrums of the same disease. Also, there are reports of keratoconus and keratoglobus, 3,14,18 as well as pellucid marginal corneal degeneration (PMCD) and keratoglobus 19,20 being clinically documented in the same patient over time. Poliquen et al 4 classified keratoglobus into two types, one being congenital and the other acquired.…”

Section: Aetiological Factorsmentioning

confidence: 99%

“…Case reports of keratoglobus with syphilis, a post-traumatic case and posterior polymorphous dystrophy have also been described in the literature. 18,21 Clinical findings…”

Section: Aetiological Factorsmentioning

confidence: 99%

“…Vogt striae and Fleischer's rings are not associated with keratoglobus. 1,14,18 As a result of the thinning and protrusion, there is high myopia with irregular astigmatism, which is the main cause of poor vision in these patients, and is difficult to treat with refractive correction. Other than poor vision patients are generally asymptomatic.…”

Section: Aetiological Factorsmentioning

confidence: 99%

“…However, owing to extreme thinning and fragility of the cornea, many cases may initially present with corneal perforations, either spontaneous or following minimal trauma. 7,10,14,18 In such cases, the diagnosis of keratoglobus must be kept in mind. This is especially important as surgical closure in these cases is difficult because of the extreme thinness of the cornea that leads to cut through of the sutures and inability for wound closure.…”

Section: Aetiological Factorsmentioning

confidence: 99%

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Keratoglobus

Wallang

Das²

2013

Eye

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Keratoglobus is a rare noninflammatory corneal thinning disorder characterised by generalised thinning and globular protrusion of the cornea. It was first described as a separate clinical entity by Verrey in 1947. Both congenital and acquired forms have been shown to occur, and may be associated with various other ocular and systemic syndromes including the connective tissue disorders. Similarities have been found with other noninflammatory thinning disorders like keratoconus that has given rise to hypotheses about the aetiopathogenesis. However, the exact genetics and pathogenesis are still unclear. Clinical presentation is characterised by progressive diminution resulting from irregular corneal topography with increased corneal fragility due to extreme thinning. Conservative and surgical management for visual rehabilitation and improved tectonic stability have been described, but remains challenging. In the absence of a definitive standard procedure for management of this disorder, various surgical procedures have been attempted in order to overcome the difficulties. This article reviews the aetiological factors, differential diagnosis, histopathology, and management options of keratoglobus.

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Section: Aetiological Factorsmentioning

confidence: 99%

“…Case reports of keratoglobus with syphilis, a post-traumatic case and posterior polymorphous dystrophy have also been described in the literature. 18,21 Clinical findings…”

Section: Aetiological Factorsmentioning

confidence: 99%

Section: Aetiological Factorsmentioning

confidence: 99%

Section: Aetiological Factorsmentioning

confidence: 99%

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Keratoglobus

Wallang

Das²

2013

Eye

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“…The advanced thinning causes the cornea to bulge forward and leads to a risk of perforation following minimal trauma, which is even reported to occur spontaneously [1, 2, 3]. High myopia and irregular astigmatism that fail to correct with spectacles lead to poor vision.…”

Section: Introductionmentioning

confidence: 99%

Limbal Stem Cell-Sparing Corneoscleroplasty with Peripheral Intralamellar Tuck: A New Surgical Technique for Keratoglobus

Jarade

Antonios

El‐Khoury

2017

Case Rep Ophthalmol

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Purpose: To describe the technique of limbal stem cell-sparing corneoscleroplasty for the management of advanced keratoglobus. Methods: A patient with bilateral advanced keratoglobus, with best-corrected visual acuity of 20/400 in the right eye and 20/200 in the left eye, underwent limbal stem cell-sparing corneoscleroplasty of the right eye. Initially, a 360-degree limbal incision with 200-μm depth was created, followed by a sublimbal tunnel dissection into the sclera, in order to conserve stem cells. Next, a limbus-to-limbus lamellar keratectomy at 200-μm depth was performed. Meanwhile, a donor corneoscleral button with preserved endothelium of the central 8 mm was fashioned. Prior to suturing the donor corneoscleral graft using a modified suturing technique to cover its scleral component, a full-thickness trephination of 8-mm diameter was completed in the central host cornea. Results: Reepithelialization occurred within the first week. No episodes of rejection, intraocular pressure spikes, or epithelial breakdown were observed postoperatively. At the 6-month follow-up, the patient had 20/70 best-corrected vision and a smooth cornea with regular astigmatism on topography. Conclusion: Limbal stem cell-sparing corneoscleroplasty is a single-step technique for restoring the structural integrity of the cornea in advanced keratoglobus while preserving the host limbal stem cells.

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Keratoconus and Corneal Noninflammatory Ectasias

Albè

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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Kératoglobe : revue de la littérature

Cited by 15 publications

References 24 publications

Keratoglobus

Keratoglobus

Limbal Stem Cell-Sparing Corneoscleroplasty with Peripheral Intralamellar Tuck: A New Surgical Technique for Keratoglobus

Keratoconus and Corneal Noninflammatory Ectasias

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