Keratoderma Climactericum (Haxthausen)

Lynch, Francis W.

doi:10.1001/archderm.1943.01510030023004

Cited by 10 publications

(9 citation statements)

References 11 publications

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“…The complementary laboratory investiga tions conducted in our 10 patients were all normal except that for microscopic pathol ogy, which revealed lesions compatible with eczema modified by more or less pro nounced lichénification. This finding agrees with the conclusions of Lynch [10], who thinks there is neurodermatitis but no spe cific histological picture of hyperestrogenic keratosis.…”

Section: Discussionsupporting

confidence: 92%

“…Hormonal assay had our particular atten tion since most authors have tended to see the triggering factor in hormonal dysrégula tion [10]; these same authors also reported cures obtained with topical or systemic es trogenic therapy [4][5][6][7][8]. It should be noted though that none of these publications ex plore ovarian, suprarenal or pituitary func- tion.…”

Section: Discussionmentioning

confidence: 99%

“…He could not find any specific etiology but empha sized the chronic nature and the difficulty of treating the disorder. Goldberg [8], Lynch [10], Block and Shapiro [4], and Dockery and Newell [7] published further observa tions, highlighting either the pathogenesis [10] or the therapy [4,7,8]. We now report on 10 new cases subjected to etiological stu dy and treated with etretinate (Tigason®).…”

Section: Introductionmentioning

confidence: 95%

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Keratoderma climactericum (Haxthausen’s Disease): Clinical Signs, Laboratory Findings and Etretinate Treatment in 10 Patients

Deschamps¹,

Leroy²,

Pédaillès³

et al. 1986

Dermatology

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10 cases of keratoderma climactericum are reported. This keratosis of the palms and soles appears late in women of menopausal age. The keratotic lesions first develop at the plantar pressure points, making walking troublesome. Involvement of the hands remains discrete. Examination for contact allergy, fungal tests, vitamin A serum levels, and sex hormones were negative or normal in all the 10 patients. Microscopy revealed a lichenified eczema with evidence of mechanical irritation. Etretinate (0.78 mg/kg/day) brought about partial or total remission of the hyperkeratosis. Pain on walking disappeared in all the patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Keratoderma climactericum (Haxthausen’s Disease): Clinical Signs, Laboratory Findings and Etretinate Treatment in 10 Patients

Deschamps¹,

Leroy²,

Pédaillès³

et al. 1986

Dermatology

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“…6 Historically, it was hypothesized that keratoderma climactericum could be a variant of palmoplantar lichen simplex chronicus. 2 Our patient's obsessive peeling of her skin may have been related to her underlying anxiety disorder and could have exacerbated her keratoderma. Importantly though, her dermatillomania developed after the onset of her palmoplantar hyperkeratosis.…”

Section: Discussionmentioning

confidence: 84%

“…1,4 In rare instances, this condition presents in younger women, including those with surgically induced menopause. 2,5 Pressure-bearing sites of bilateral soles are often affected first, followed by palmar involvement. Less frequently, hyperkeratosis is unilateral or limited to the palms.…”

Section: Case Reportmentioning

confidence: 99%

Palmoplantar keratoderma climactericum successfully treated with topical oestrogen

Norman,

Obed,

Chen

et al. 2023

JEADV Clinical Practice

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Keratoderma climactericum is characterized by palmoplantar hyperkeratosis developing after the onset of menopause. Although rare, keratoderma climactericum can profoundly impact quality of life and may be refractory to prescription‐strength topical steroids and keratolytics. We report a 52‐year‐old female with a 1‐year history of palmoplantar keratoderma. She had a medical history of generalized anxiety disorder and had reached menopause 2 years before presentation. Previously failed treatments included clotrimazole 1% cream twice daily, triamcinolone 0.1% cream twice daily, and betamethasone 0.05% cream mixed with tazarotene 0.1% cream twice daily. She was diagnosed with keratoderma climactericum, and conjugated oestrogen 0.625 mg/g cream twice daily was initiated. After 4 weeks, she had dramatically reduced erythema and hyperkeratosis of her bilateral palms and soles. No adverse effects to treatment were reported. Although the utility of topical oestrogen for keratoderma climactericum has been debated, our case provides further evidence for its efficacy and safety.

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Keratoderma Climactericum

Garbe¹

1944

Arch Derm Syphilol

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Keratoderma Climactericum (Haxthausen)

Cited by 10 publications

References 11 publications

Keratoderma climactericum (Haxthausen’s Disease): Clinical Signs, Laboratory Findings and Etretinate Treatment in 10 Patients

Keratoderma climactericum (Haxthausen’s Disease): Clinical Signs, Laboratory Findings and Etretinate Treatment in 10 Patients

Palmoplantar keratoderma climactericum successfully treated with topical oestrogen

Keratoderma Climactericum

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