Keratoconus Prevalence Among High School Students in New Zealand

Papaliʼi-Curtin, Alistair T; Cox, Rachel; Ma, Tiffany; Woods, Lisa; Covello, Albie; Hall, Reece C

doi:10.1097/ico.0000000000002054

Cited by 62 publications

(72 citation statements)

References 47 publications

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“…eratoconus is a leading cause for visual impairment in adolescents and young adults which, untreated, can lead to legal blindness [1][2][3][4][5][6][7] . The prevalence of keratoconus varies between ethnic groups, with figures as high as 1.2% reported in some predominantly European populations 8 , to 2.3-3.3% in Maori or Iranian populations 9,10 . A high occurrence rate in first degree relatives, and concordance in twins, suggest that keratoconus has a strong genetic component 11,12 .…”

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confidence: 99%

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

et al. 2021

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Keratoconus is characterised by reduced rigidity of the cornea with distortion and focal thinning that causes blurred vision, however, the pathogenetic mechanisms are unknown. It can lead to severe visual morbidity in children and young adults and is a common indication for corneal transplantation worldwide. Here we report the first large scale genome-wide association study of keratoconus including 4,669 cases and 116,547 controls. We have identified significant association with 36 genomic loci that, for the first time, implicate both dysregulation of corneal collagen matrix integrity and cell differentiation pathways as primary disease-causing mechanisms. The results also suggest pleiotropy, with some disease mechanisms shared with other corneal diseases, such as Fuchs endothelial corneal dystrophy. The common variants associated with keratoconus explain 12.5% of the genetic variance, which shows potential for the future development of a diagnostic test to detect susceptibility to disease.

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confidence: 99%

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

et al. 2021

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“…Values that are 5 to 10-fold higher than previously reported in relatively large population studies [11]. Also, a study from New Zealand found that in a Maori population, the prevalence of KC among high school children was unusually high at 1:45 [13].…”

Section: Introductionmentioning

confidence: 62%

Prevalence of Keratoconus in Refractive Surgery Practice Population in North Macedonia

Gilevska¹,

Biščević

Kostovska³

et al. 2021

Preprint

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Purpose: To determine the prevalence of keratoconus (KC) in relation to ethnicity in N. Macedonia. Methods: This was a cross-sectional, interventional retrospective study. Chart reviews were performed for all new patients attending between January 2016 and January 2020 at the Sistina Ophthalmology Hospital in Skopje. All patients were screened, KC diagnosis and classification was based on the corneal topography. Ethnicity and gender classifications were according to patients’ self-opinions. Results: A total of 2812 patients charts reviewed. The mean age was 31.71 years (SD, ±9.73), 1209 (43%) were male. 2050 (72.9%) declared themselves as Macedonians, 649 (23.1%) Albanians, 76 (2.7%) Turks and 37 (1.3%) in other ethnicities. Differences in age between the ethnic groups was statistically significant (𝑥2=90.225, p<0.001). KC was diagnosed in 343 patients (12.2%), 9 were KC suspects and 6 were pellucid marginal degeneration. KC was more frequent in males (n=246, 71.7% of total) and skewed towards younger patients. Increasing patients’ age decreased the odds of KC diagnosis by 3.7%(95% CI:1.8%-4.4%) per annum. Males were 4 times more likely to be diagnosed with KC (AOR=4.01;95% CI:3.12–5.16). In comparison with Macedonian patients, Turks were more likely to be diagnosed with KC (AOR=4.09;95%CI:2.47–6.78). There was no difference between Macedonians and Albanians (p=0.08). Conclusion: The prevalence of KC at a refractive surgery practice in N.Macedonia is much higher compared with general population and similar to the prevalence in Middle East Asia. Nationwide screening programs are needed to diagnose the disease earlier.

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“…The prevalence of Keratoconus is seen in the Arabic region as well as other Asian countries. Keratoconus can impact old as well as young so the early detection can help in preventing the irreversible damage [4][5][6][7][8]. Hence not only the early detection but the better methods of diagnosis of keratoconus is needed.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Deep Learning Networks for Keratoconus Detection Using Corneal Topographic Images

Gandhi

Satani

Bhuva

et al. 2021

Communications in Computer and Information Science

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Keratoconus is an eye disease of 'deformation of corneal curvature' caused due to 'non-inflammatory progressive thinning' resulting into loss of elasticity in cornea and protrudes a cone shape formation that ultimately reduces visual acuity. For many years, researchers have worked towards accurate detection of keratoconus (KCN) as it is essential checkup before any refractive surgery demanding quick as well as precise clinical diagnosis and treatments of keratoconus prior to LASIK. In our study, we have firstly derived two variants of the original corneal topographies namely 'images with edges' and 'images with edges-and-mask', as data sets. The deep neural network techniques such as Artificial Neural Network (ANN), Convolutional Neural Network (CNN) and pertained VGG16 model are applied on original 'corneal topographies' as well as on the two of its variants and the results obtained are presented. Keywords: Keratoconus Á Corneal topography Á ATLAS 9000 Á ANN Á CNN Á VGG16 Á Canny edge detection Á Edges with mask

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Keratoconus Prevalence Among High School Students in New Zealand

Cited by 62 publications

References 47 publications

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus

Prevalence of Keratoconus in Refractive Surgery Practice Population in North Macedonia

Evaluation of Deep Learning Networks for Keratoconus Detection Using Corneal Topographic Images

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