Keratoconus development risk factors: A contralateral eye study

Magalhaes, Otavio A.; Fujihara, Fernanda Mari Fagundes; Brittes, Eduardo B.N. de; Tavares, Rafael N.

doi:10.1016/j.xjec.2020.02.003

Cited by 6 publications

(10 citation statements)

References 14 publications

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“…Signs and symptoms of blepharitis and dry eyes were shown to be more prevalent among KC participants than in those without KC [21]. We have also found that more than half of participants with asymmetrical KC had signs of blepharitis and dry eyes [14 ▪ ]. In addition to blepharitis, evaporative dry eye due to extended computer, video-game, and/or cellphone usage induced eye manipulation and could account in part for the recent increase in the prevalence of KC in the young population [22].…”

Section: Atopy Blepharitis and Dry Eyessupporting

confidence: 59%

“…Many studies have shown an association between KC and atopic disorders, such as asthma and allergic rhinitis [17,18]. We have shown that approximately two-thirds of the participants with marked asymmetrical KC had a positive history of allergic rhinitis, and half of those had asthma [14 ▪ ]. Likewise, the collaborative longitudinal evaluation of keratoconus study found allergic rhinitis in 53% of KC subjects [19].…”

Section: Atopy Blepharitis and Dry Eyesmentioning

confidence: 89%

“…The bending response of the cornea can also occur due to eye compression by the arm or hand at night when a person sleeps on his/her stomach or simply by as a result of unconscious rubbing [13]. In a previous paper, we have demonstrated a positive association between increased eye rubbing frequency and advanced KC [14 ▪ ].…”

Section: Mechanical Manipulationmentioning

confidence: 91%

“…The 2015 international project Global Consensus on Keratoconus and Ectatic Diseases stated that ‘unilateral KC clinical presentation may occur in a predisposed individual because of asymmetric environmental factors, such as eye rubbing’ [32]. In order to investigate these cases and prevent potential confounding variables, such as ethnic differences and hormonal and genetics factors, the author used the same individuals as case and control eyes with marked asymmetrical KC [14 ▪ ]. Although an increase in patient-reported frequency of manipulation in eyes with advanced KC was observed, we could not find any significant difference in ocular surface parameters (blepharitis signs and dry eyes tests) between cases and controls [14 ▪ ].…”

Section: Unilateral and Very Asymmetrical Keratoconusmentioning

confidence: 99%

See 3 more Smart Citations

The role of environment in the pathogenesis of keratoconus

Magalhães¹,

Gonçalves²,

Gatinel

2021

Current Opinion in Ophthalmology

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Purpose of reviewThis study was conducted to demonstrate the importance of the environment in keratoconus (KC) genesis. Recent findingsGenetic-related connective tissue disorders demonstrate the inconsistency of theories regarding KC pathogenesis since no corneal steepening was observed in the majority of these patients. Despite recent advances and decades of research into the genetics of KC, the identification of disease-causing KC genes has been frustrating. Variants found based on genome-wide and next-generation sequencing only seem to account for a small number of cases or play a limited role in KC pathogenesis.

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Section: Atopy Blepharitis and Dry Eyessupporting

confidence: 59%

Section: Atopy Blepharitis and Dry Eyesmentioning

confidence: 89%

Section: Mechanical Manipulationmentioning

confidence: 91%

Section: Unilateral and Very Asymmetrical Keratoconusmentioning

confidence: 99%

See 2 more Smart Citations

The role of environment in the pathogenesis of keratoconus

Magalhães¹,

Gonçalves²,

Gatinel

2021

Current Opinion in Ophthalmology

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“…It is part of the corneal ectatic disorders, along with pellucid marginal degeneration and post-corneal refractive surgery keratectasia. The etiology is mostly genetic [ 1 ], but there are some risk factors, such as eye rubbing [ 2 ], which are also considered to play a role. Atopy seems to play a role, as well.…”

Section: Introductionmentioning

confidence: 99%

Current approaches in management of patients with keratoconus

Gănescu

2022

Medicine and Pharmacy Reports

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Keratoconus is a relatively frequent eye disease, especially in young patients, in which the cornea gradually thins and deforms in a cone shape. In the past, it could be treated only with glasses, rigid contact lenses or, for advanced cases, penetrating corneal transplant. Nowadays, corneal cross-linking, intracorneal ring segments implantation or deep anterior lamellar keratoplasty are available options of treatment, along with the above mentioned ones. Several studies focused on this disease and its management attempted to establish the applicability of these treatment methods in current practice. In the early stages, glasses or soft toric contact lenses are able to correct the astigmatism, but, as the disease progresses, rigid contact lenses are indicated. Corneal cross-linking is done in order to slow down or even stop the progression of the disease. Implanting intracorneal ring segments helps improve visual acuity in patients with low vision that cannot be corrected otherwise. Advanced stages need corneal transplant, either penetrating or anterior lamellar, depending on each patient’s ocular characteristics. Thus, keratoconus treatment is individualized for every patient, according to the stage of the disease. Moreover, because of the new developed technology, keratoconus patients can benefit from efficient treatment, in much safer conditions.

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Keratoconus – Still behind the cone

Dua

2020

Journal of EuCornea

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Keratoconus development risk factors: A contralateral eye study

Cited by 6 publications

References 14 publications

The role of environment in the pathogenesis of keratoconus

The role of environment in the pathogenesis of keratoconus

Current approaches in management of patients with keratoconus

Keratoconus – Still behind the cone

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