Keratoconus and granular dystrophy

Wilson, Clare; D’Ath, P.; Parmar, Dipak N.; Sykakis, Evripidis

doi:10.1136/bcr-2014-205584

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…A lower SSI in GCD compared to normal corneas confirmed these changes in involved corneas. In addition, the present findings are in line with other studies that simultaneously reported the association of GCD with keratoconus [ 42 , 43 , 44 , 45 , 46 ].…”

Section: Discussionsupporting

confidence: 93%

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy

Heidari

Momeni‐Moghaddam

Jadidi

et al. 2022

JCM

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Background: The aim of this study was to assess stress-strain index (SSI) and corneal biomechanical parameters in eyes with granular corneal dystrophy (GCD). Methods: This case-control study included 12 eyes of 12 patients with GCD (mean age 45.2 ± 18.7 years) and 20 eyes of 20 healthy individuals (mean age 54.4 ± 3.8 years). In addition to SSI, dynamic corneal response (DCR) parameters were assessed at the first and second applanation, including length (AL1, AL2), velocity (AV1, AV2), time (AT1, AT2), and deformation amplitude (DA A1, DA A2), and at the highest concavity (HC) phase, including DA, peak distance (PD), radius (HCR), and DA ratio (DAR 1 and 2 mm), by Corvis ST. Central corneal thickness (CCT) and biomechanically corrected intraocular pressure (bIOP) were considered covariates in comparing DCR parameters between the two groups. Results: SSI was statistically significantly lower in eyes with GCD than in normal eyes (p = 0.04). The corneal velocity towards the first applanation was 0.02 m/s faster in the GCD eyes AV1 (0.15 ± 0.02 vs. 0.13 ± 0.02 m/s, p < 0.001) and IR (7.48 ± 1.01 vs. 6.80 ± 1.22 mm, p = 0.003) parameters were significantly higher in the GDC group, while AT1 (7.33 ± 0.66 vs. 7.47 ± 0.36 ms, p = 0.002) and HCR (7.42 ± 0.76 vs. 8.20 ± 1.08 mm, p = 0.014) were significantly lower in the normal group. Conclusions: GCD led to a change in biomechanical properties of the cornea. SSI refers to fewer stiff corneas in GDC than normal.

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Section: Discussionsupporting

confidence: 93%

Changes in Stress-Strain Index and Corneal Biomechanics in Granular Corneal Dystrophy

Heidari

Momeni‐Moghaddam

Jadidi

et al. 2022

JCM

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“…Although KTCN is sometimes referred to as a corneal dystrophy, it is not included in International Classification of Corneal Dystrophies (IC3D) (Weiss et al 2008 ) and should be distinguished from this group of corneal diseases. However, co-occurrence of KTCN with many types of corneal dystrophies, including Avellino and Fuchs dystrophies (Igarashi et al 2003 ; Salouti et al 2010 ; Wilson et al 2014 ), may indicate that common molecular mechanisms in the pathogenesis of these disorders are involved.…”

Section: Introductionmentioning

confidence: 99%

Genomic strategies to understand causes of keratoconus

Karolak

Gajęcka

2016

Mol Genet Genomics

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Keratoconus (KTCN) is a degenerative disorder of the eye characterized by the conical shape and thinning of the cornea. The abnormal structure of KTCN-affected cornea results in loss of visual acuity. While many studies examine how environmental factors influence disease development, finding the genetic triggers has been a major emphasis of KTCN research. This paper focuses on genomic strategies that were implemented for finding candidate genes, including linkage and association studies, and presents different approaches of mutation screening. The advantages and limitations of particular tools are discussed based on literature and personal experience. Since etiology underlying KTCN is complex, numerous findings indicating heterogeneity of genetic factors involved KTCN etiology are presented.

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“…GCD with keratoconus is rarely reported. [ 1 2 3 4 ] Although no evidence-based analysis has linked this association, many theories have been proposed, including abnormal synthetic activity of keratocytes and degeneration of defective basal epithelial cells, speculated to occur in both. [ 2 ] While GCD is clinically obvious, this case emphasizes the need to identify associated factors in effective planning and management.…”

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confidence: 99%