Keratoacanthoma: Update on the Debate

Nirenberg, Alexander; Steinman, Howard K.; Dixon, A. F. G.

doi:10.1097/dad.0000000000001872

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…Keratoacanthoma (KA) is a malignancy displaying a bi-phasic growth pattern characterized by a fast growing phase generally followed by involution. As most of the other SCs, UV exposure is a risk factor, since KA mostly occurs on sun-damaged skin [ 37 ]. There is not a consensus among authors on whether KA is a variant of SCC or a separate entity; however, a certain differential diagnosis between these two malignancies is of primary need, since KA, unlike SCC, is characterized by a good prognosis due to its inclination to spontaneous involution [ 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers

Campagna

Pozzi

Salvolini

et al. 2021

Cancers

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Skin cancers (SC) collectively represent the most common type of malignancy in white populations. SC includes two main forms: malignant melanoma and non-melanoma skin cancer (NMSC). NMSC includes different subtypes, namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Merkel cell carcinoma (MCC), and keratoacanthoma (KA), together with the two pre-neoplastic conditions Bowen disease (BD) and actinic keratosis (AK). Both malignant melanoma and NMSC are showing an increasing incidence rate worldwide, thus representing an important challenge for health care systems, also because, with some exceptions, SC are generally characterized by an aggressive behavior and are often diagnosed late. Thus, identifying new biomarkers suitable for diagnosis, as well as for prognosis and targeted therapy is mandatory. Nicotinamide N-methyltransferase (NNMT) is an enzyme that is emerging as a crucial player in the progression of several malignancies, while its substrate, nicotinamide, is known to exert chemopreventive effects. Since there is increasing evidence regarding the involvement of this enzyme in the malignant behavior of SC, the current review aims to summarize the state of the art as concerns NNMT role in SC and to support future studies focused on exploring the diagnostic and prognostic potential of NNMT in skin malignancies and its suitability for targeted therapy.

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Section: Introductionmentioning

confidence: 99%

Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers

Campagna

Pozzi

Salvolini

et al. 2021

Cancers

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“…Allerdings kann die histologische Differenzierung schwierig sein, da nicht immer adäquate und komplette Probeentnahmen/Exzisionen erfolgen, die eine vollständige Architektureinschätzung ermöglichen. Hier spielen überlappende mikroskopische Kriterien, mögliche Varianten des Keratoakanthoms mit Aggressivitätsmerkmalen sowie medico-legale Überlegungen eine Rolle [5]. In einer retrospektiven Studie aus Registerdaten der histopathologischen Zentren in England und Irland ließen sich große Zentrenunterschiede bezüglich der histologischen Diagnosestellung, die nicht alleine durch die Epidemiologie erklärbar waren, feststellen [6].…”

Section: Clinical Letterunclassified

Janus‐Gesicht des Keratoakanthoms – Berücksichtigung bei der Berufskrankheit BK 5103?

Gina

Thielitz²,

Fartasch

2022

J Deutsche Derma Gesell

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“…Keratoacanthoma (KA) is a cutaneous tumor that commonly occurs as an isolated lesion on sun‐exposed skin in elderly patients. Evidence suggests that KA is a distinct clinical variant of well‐differentiated squamous cell carcinoma (SCC), although this is still a subject of debate (Nagarajan, 2020; Nirenberg et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a HPLC–UV based method for the extraction and quantification of methotrexate in the skin

Giulio

Padula

Pescina

et al. 2022

Biomedical Chromatography

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An innovative and sensitive HPLC-UV method for the extraction and quantification of methotrexate (MTX) in skin layers was developed and validated. Owing to the physico-chemical characteristics of the drug and the nature of the tissue, it was necessary to use folic acid (FA) as an internal standard for MTX quantification in the dermis. MTX (and FA) analysis was performed on a Phenomenex Jupiter C 18 column, using a 50 mM sodium acetate buffer (pH 3.6) and methanol mixture (87:13, v/v) as mobile phase, pumped at 1 ml/min. The absorbance was monitored at 290 nm. The method was selective, linear in the range 0.11-8.49 μg/ml for extraction solvent and 0.05-8.94 μg/ml for pH 7.4 phosphate-buffered saline, precise and accurate, with lower limits of quantitation of 0.11 μg/ml (extraction solvent) and 0.05 μg/ml (pH 7.4 phosphate-buffered saline). The method developed is suitable for the quantification of MTX in skin layers at the end of in vitro permeation experiments; the overall mass balance was 96.5 ± 1.4%, in line with the requirements of the Organisation for Economic Co-operation and Development guideline for the testing of the chemicals (Skin absorption: in vitro method).

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Keratoacanthoma: Update on the Debate

Abstract: FIGURE 1. Low-power microscopic view of a keratoacanthoma.FIGURE 2. Clinical photograph of keratoacanthoma.

Cited by 8 publications

References 26 publications

Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers

Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers

Janus‐Gesicht des Keratoakanthoms – Berücksichtigung bei der Berufskrankheit BK 5103?

Development and validation of a HPLC–UV based method for the extraction and quantification of methotrexate in the skin

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